TRIM27

Gene Symbol	TRIM27
Entrez Gene	5987
Alt Symbol	RFP, RNF76
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 27
Other Description	RFP transforming protein|RING finger protein 76|ret finger protein|tripartite motif protein TRIM27|tripartite motif-containing 27|tripartite motif-containing protein 27|zinc finger protein RFP
Swissprots	P14373 Q9BZY6 Q5ST26 A2BE15 Q9UJL3 Q6NXR9 Q5RJA8 Q6LA73
Accessions	AAF32265 CAB06480 CAI19959 EAX03176 EAX03177 P14373 AB209885 BAD93122 AF230393 AAG50172 AF230394 AAG50173 AJ420519 AX776009 CAE11704 AX776011 CAE11705 BC013580 AAH13580 BC066924 AAH66924 DQ890982 ABM81908 DQ894156 ABM85082 J03407 AAA36564 NM_006510 NP_006501 NM_030950
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T- cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double- stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Early endosome {ECO:0000269|PubMed:1437549, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:9247190}. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). {ECO:0000250, ECO:0000269|PubMed:23452853}.
Tissue Specificity	Expressed in testis namely within the seminiferous tubules. {ECO:0000269|PubMed:12445133}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRIM27 CRISPR/Cas9 KO Plasmid (h) - sc-406447 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIM27 HDR Plasmid (h) - sc-406447-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIM27 Double Nickase Plasmid (h) - sc-406447-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIM27 Double Nickase Plasmid (h2) - sc-406447-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIM27 CRISPR Activation Plasmid (h) - sc-406447-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIM27 CRISPR Activation Plasmid (h2) - sc-406447-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIM27 Lentiviral Activation Particles (h) - sc-406447-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIM27 Lentiviral Activation Particles (h2) - sc-406447-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIM27 siRNA (h) - sc-61712 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TRIM27 shRNA Plasmid (h) - sc-61712-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TRIM27 shRNA (h) Lentiviral Particles - sc-61712-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TRIM27 RNAi - H00005987-R07 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU113391 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21966 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21966 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08107 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08107

TRIM27 siRNA (Human) - CRH4055 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SignalSilence ® TRIM27 siRNA I - 15157 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

TRIM27 RNAi - H00005987-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TRIM27 - MBS8221198 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TRIM27 (NM_006510.4) - SHH434532 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human TRIM27(NM_006510.4) - SHL093762 from Creative biogene Category siRNA Species Reactivities Human

Human TRIM27 siRNA - orb264557 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TRIM27 shRNA Plasmid (Human) - CHH4055 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TRIM27 miRNA 3'UTR clone - MiUTR1H-10728 from Creative biogene Species Reactivities Human

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