TRIM27

Gene Symbol	TRIM27
Entrez Gene	5987
Alt Symbol	RFP, RNF76
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 27
Other Description	RFP transforming protein|RING finger protein 76|ret finger protein|tripartite motif protein TRIM27|tripartite motif-containing 27|tripartite motif-containing protein 27|zinc finger protein RFP
Swissprots	P14373 Q9BZY6 Q5ST26 A2BE15 Q9UJL3 Q6NXR9 Q5RJA8 Q6LA73
Accessions	AAF32265 CAB06480 CAI19959 EAX03176 EAX03177 P14373 AB209885 BAD93122 AF230393 AAG50172 AF230394 AAG50173 AJ420519 AX776009 CAE11704 AX776011 CAE11705 BC013580 AAH13580 BC066924 AAH66924 DQ890982 ABM81908 DQ894156 ABM85082 J03407 AAA36564 NM_006510 NP_006501 NM_030950
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T- cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double- stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Early endosome {ECO:0000269|PubMed:1437549, ECO:0000269|PubMed:23452853, ECO:0000269|PubMed:9247190}. Note=Nuclear or cytoplasmic depending on the cell type (By similarity). Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853). {ECO:0000250, ECO:0000269|PubMed:23452853}.
Tissue Specificity	Expressed in testis namely within the seminiferous tubules. {ECO:0000269|PubMed:12445133}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RFP full length protein - ab51993 from Abcam Category Protein Source E. coli

Sea anenome (Discosoma) RFP peptide - ab41334 from Abcam Category Peptide

Sea anenome (Discosoma) RFP peptide - ab41335 from Abcam Category Peptide

TRIM27 peptide - ab90956 from Abcam Category Peptide

TRIM27 Antibody Blocking Peptide - LS-E3689 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM27 Antibody Blocking Peptide - LS-E12341 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM27 Antibody Blocking Peptide - LS-E12340 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant RFP Protein - NBP1-99583 from Novus Biologicals Category Protein Prices $295.00 Sizes 100 µg Source E. coli

TRIM27-Antibody-C-term-Blocking-Peptide - BP14892b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RFP recombinant protein - GTX65496 from GeneTex Category Protein Prices $319.00 Sizes 100 μg Source E. coli

RFP recombinant protein - GTX65495 from GeneTex Category Protein Prices $1,949.00 Sizes 1 mg Source E. coli

dsRed Fluorescent protein - 30R-2809 from Fitzgerald Category Protein Prices $395.00 Sizes 100 µg Source E.coli Species Human

TRIM27 Blocking Peptide - 33R-4638 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRIM27 Blocking Peptide - 33R-2667 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRIM27 fusion protein - ag2849 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Zinc finger protein RFP(TRIM27) - CSB-YP024464HU CSB-EP024464HU CSB-BP024464HU CSB-MP024464HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TRIM27 / RFP / RNF76 (full length, N-term HIS tag) - TP760030 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Zinc finger protein RFP (TRIM27) , Recombinant Protein - MBS949062 from MyBioSource Category Protein Prices $2,140.00, $2,140.00, $2,605.00, $2,605.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

TRIM27 Recombinant Protein Antigen - NBP2-13482PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRIM27-Antibody-N-Term-Blocking-peptide - BP10035a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRIM27 Peptide, Human - M34GP16579H from Creative Peptides Category Peptide Source Synthetic. Species Human

RFP protein - orb345960 from Biorbyt Category Protein Prices $604.00 Sizes 100 μg

TRIM27 Recombinant Protein Antigen - NBP2-54993PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RFP, Recombinant Protein - MBS168749 from MyBioSource Category Protein Prices $365.00, $1,320.00 Sizes 100 µg, 500 µg (5x0.1 mg)

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