| Gene Symbol | IL1A |
|---|---|
| Entrez Gene | 3552 |
| Alt Symbol | IL-1A, IL1, IL1-ALPHA, IL1F1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 1, alpha |
| Other Description | IL-1 alpha|hematopoietin-1|interleukin-1 alpha|preinterleukin 1 alpha|pro-interleukin-1-alpha |
| Swissprots | Q7RU02 Q53QF9 P01583 |
| Accessions | AAM96189 AAX93054 CAA27448 CAD29871 EAW73604 P01583 AK314850 BAG37367 BC013142 AAH13142 BC035169 BT007014 AAP35660 CA307202 CR457414 CAG33695 DQ890675 ABM81601 DQ893856 ABM84782 M15329 AAA59133 X02531 CAA26371 X02851 CAA26604 X56086 CAA39566 NM_000575 NP_000566 |
| Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| Subcellular Location | Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
| Top Pathways | Tuberculosis, Measles, Influenza A, Salmonella infection, Inflammatory bowel disease (IBD) |