| Gene Symbol |
IL1A
|
| Entrez Gene |
3552
|
| Alt Symbol |
IL-1A, IL1, IL1-ALPHA, IL1F1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 1, alpha
|
| Other Description |
IL-1 alpha|hematopoietin-1|interleukin-1 alpha|preinterleukin 1 alpha|pro-interleukin-1-alpha
|
| Swissprots |
Q7RU02 Q53QF9 P01583
|
| Accessions |
AAM96189 AAX93054 CAA27448 CAD29871 EAW73604 P01583 AK314850 BAG37367 BC013142 AAH13142 BC035169 BT007014 AAP35660 CA307202 CR457414 CAG33695 DQ890675 ABM81601 DQ893856 ABM84782 M15329 AAA59133 X02531 CAA26371 X02851 CAA26604 X56086 CAA39566 NM_000575 NP_000566
|
| Function |
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
|
| Subcellular Location |
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
|
| Top Pathways |
Tuberculosis, Measles, Influenza A, Salmonella infection, Inflammatory bowel disease (IBD)
|
