Fgfr1

Gene Symbol	Fgfr1
Entrez Gene	14182
Alt Symbol	AW208770, Eask, FLG, Fgfr-1, Flt-2, Hspy, MFR, bFGF-R-1, c-fgr
Species	Mouse
Gene Type	protein-coding
Description	fibroblast growth factor receptor 1
Other Description	basic fibroblast growth factor receptor 1|proto-oncogene c-Fgr
Swissprots	Q9QZM7 Q60830 Q61562 Q01736 Q8CFK8 E9Q2P4 P16092 Q80T10
Accessions	AAD38071 AAF82386 EDL32833 EDL32834 EDL32835 EDL32836 P16092 AF176552 AAF05312 AI480534 AK028354 BAC25899 AK034295 BAC28662 AK049704 AK086091 AK167639 BAE39690 BC010200 AAH10200 BC033447 AAH33447 BC053921 BU611199 CB524826 CF532036 M28998 AAA37290 M33760 AAA37622 M65053 AAA37620 S47233 S74765 AAB32844 U22324 AAC52182 U23445 AAC52183 X51893 CAA36175 X57790 CAA40932 XM_006509010 XP_006509073 XM_006509012 XP_006509075 XM_006509013 XP_006509076 XM_011242120 XP_011240422 XM_011242121 XP_011240423 XM_011242122 XP_011240424 XM_011242123 XP_011240425 NM_001079908 NP_001073377 NM_001079909 NP_001073378 NM_010206 NP_034336
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to
Subcellular Location	Isoform 5: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:10821861}.
Top Pathways	Adherens junction, PI3K-Akt signaling pathway, MAPK signaling pathway, Signaling pathways regulating pluripotency of stem cells, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Anti-FGFR1 alpha (phospho Y654) antibody [EP843(2)] - ab134043 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP843(2)

ANTI-MOUSE FGFR1 (C-TERM) antibody produced in rabbit - SAB1302592 from Sigma-Aldrich Prices $326.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

FGF Receptor 1 Antibody (OAMA01774) - OAMA01774 from Aviva Systems Biology Prices $785.00 Sizes 250 µg Host Mouse Clonality Monoclonal Clone M5G10

Fgfr1 Antibody - N-terminal region (ARP63080_P050) - ARP63080_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Mouse-Fgfr1-Antibody-C-term - AP14840b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

FGR antibody, C-term - GTX95551 from GeneTex Prices $319.00 Sizes 100 μg Host Goat Clonality Polyclonal

Mouse Fgfr1 Antibody - C-terminal region (OAAB11171) - OAAB11171 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

FGF Receptor antibody (Tyr154) - 70R-34138 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FGFR1 antibody - 70R-35247 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FGFR1/2 antibody (Tyr463/466) - 70R-34419 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FGFR1 antibody - 70R-36800 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FGFR1 antibody (Tyr654) - 70R-36927 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FGF Receptor antibody - 70R-34139 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Fibroblast Growth Factor Receptor 1 antibody - orb170497 from Biorbyt Prices $323.00, $493.00 Sizes 100 μg, 200 μg Host Rabbit Clonality Polyclonal

FGFR1/2 antibody - 70R-34418 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

FGFR1 antibody (Tyr766) - 70R-35505 from Fitzgerald Host Rabbit Clonality Polyclonal

FGFR1 antibody (Tyr154) - 70R-37431 from Fitzgerald Prices $295.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Phospho-FGF Receptor 1 - Y654, Polyclonal Antibody - 25-AP0037 from ARP American Research Products Prices $279.00, $549.00 Sizes 50 µg, 200 µg Host Rabbit Clonality Polyclonal

Anti-FGFR1 antibody - STJ72699 from St John's Laboratory Ltd Host Goat Clonality Polyclonal

Fibroblast Growth Factor Receptor 1 (FGFR1), Polyclonal Antibody - MBS2013991 from MyBioSource Prices $405.00 Sizes 100 µg Clonality Polyclonal

Fibroblast Growth Factor Receptor 1 (FGFR1), Polyclonal Antibody - MBS2001567 from MyBioSource Prices $375.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Fibroblast Growth Factor Receptor 1 (FGFR1), Polyclonal Antibody - MBS2001403 from MyBioSource Prices $150.00, $295.00, $470.00 Sizes 20 µg, 100 µg, 200 µg Host Rabbit Clonality Polyclonal

FGF Receptor 1 Antibody - GWB-68DD5A from Genway Biotech Prices $903.00 Sizes 250 µg Host Mouse Clonality Monoclonal Clone M5G10

FGF Receptor 1 Antibody - GWB-3F2BFE from Genway Biotech Prices $830.00 Sizes 250 µg Host Mouse Clonality Monoclonal Clone M17D10

FGF Receptor 1 Antibody - GWB-150127 from Genway Biotech Prices $830.00 Sizes 250 µg Host Mouse Clonality Monoclonal Clone M19B2

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