Fgfr1
| Gene Symbol | Fgfr1 |
|---|---|
| Entrez Gene | 14182 |
| Alt Symbol | AW208770, Eask, FLG, Fgfr-1, Flt-2, Hspy, MFR, bFGF-R-1, c-fgr |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | fibroblast growth factor receptor 1 |
| Other Description | basic fibroblast growth factor receptor 1|proto-oncogene c-Fgr |
| Swissprots | Q9QZM7 Q60830 Q61562 Q01736 Q8CFK8 E9Q2P4 P16092 Q80T10 |
| Accessions | AAD38071 AAF82386 EDL32833 EDL32834 EDL32835 EDL32836 P16092 AF176552 AAF05312 AI480534 AK028354 BAC25899 AK034295 BAC28662 AK049704 AK086091 AK167639 BAE39690 BC010200 AAH10200 BC033447 AAH33447 BC053921 BU611199 CB524826 CF532036 M28998 AAA37290 M33760 AAA37622 M65053 AAA37620 S47233 S74765 AAB32844 U22324 AAC52182 U23445 AAC52183 X51893 CAA36175 X57790 CAA40932 XM_006509010 XP_006509073 XM_006509012 XP_006509075 XM_006509013 XP_006509076 XM_011242120 XP_011240422 XM_011242121 XP_011240423 XM_011242122 XP_011240424 XM_011242123 XP_011240425 NM_001079908 NP_001073377 NM_001079909 NP_001073378 NM_010206 NP_034336 |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to |
| Subcellular Location | Isoform 5: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10821861}. |
| Top Pathways | Adherens junction, PI3K-Akt signaling pathway, MAPK signaling pathway, Signaling pathways regulating pluripotency of stem cells, Prostate cancer |
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