| Gene Symbol |
PACSIN1
|
| Entrez Gene |
29993
|
| Alt Symbol |
SDPI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein kinase C and casein kinase substrate in neurons 1
|
| Other Description |
protein kinase C and casein kinase substrate in neurons protein 1|syndapin 1|syndapin I|syndapin-1
|
| Swissprots |
Q9BY11 Q9P2G8
|
| Accessions |
EAX03785 EAX03786 EAX03787 Q9BY11 AB037800 BAA92617 AF242529 AAK29206 AK289956 BAF82645 AK294132 BAG57460 AL834211 CAD38895 AM393510 CAL38387 BC040228 AAH40228 BC128219 AAI28220 BP211882 BP251080 DC312410 DQ892478 ABM83404 DQ895689 ABM86615 XM_011514541 XP_011512843 NM_001199583 NP_001186512 NM_020804 NP_065855
|
| Function |
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain and, at much lower levels, in heart and pancreas. {ECO:0000269|PubMed:11179684}.
|