PACSIN1

Gene Symbol	PACSIN1
Entrez Gene	29993
Alt Symbol	SDPI
Species	Human
Gene Type	protein-coding
Description	protein kinase C and casein kinase substrate in neurons 1
Other Description	protein kinase C and casein kinase substrate in neurons protein 1|syndapin 1|syndapin I|syndapin-1
Swissprots	Q9BY11 Q9P2G8
Accessions	EAX03785 EAX03786 EAX03787 Q9BY11 AB037800 BAA92617 AF242529 AAK29206 AK289956 BAF82645 AK294132 BAG57460 AL834211 CAD38895 AM393510 CAL38387 BC040228 AAH40228 BC128219 AAI28220 BP211882 BP251080 DC312410 DQ892478 ABM83404 DQ895689 ABM86615 XM_011514541 XP_011512843 NM_001199583 NP_001186512 NM_020804 NP_065855
Function	Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. {ECO:0000250}.
Tissue Specificity	Highly expressed in brain and, at much lower levels, in heart and pancreas. {ECO:0000269|PubMed:11179684}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PACSIN1 full length protein - ab131867 from Abcam Category Protein Source Wheat germ Species Human

Human PACSIN1 peptide - ab45457 from Abcam Category Peptide Species Human

Syndapin I / PACSIN1 Antibody Blocking Peptide - LS-E10711 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Syndapin I / PACSIN1 Antibody Blocking Peptide - LS-E25280 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Syndapin I / PACSIN1 Antibody Blocking Peptide - LS-E9483 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Syndapin I / PACSIN1 Antibody Blocking Peptide - LS-E9484 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PACSIN1 Protein - H00029993-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PACSIN1 Peptide - P3086 from Novus Biologicals Category Peptide Species Human

PACSIN1 Peptide - P3085 from Novus Biologicals Category Peptide Species Human

PACSIN1-Antibody-Center-Blocking-Peptide - BP8087c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PACSIN1-Antibody-N-term-Blocking-Peptide - BP8087a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PACSIN1 Protein - GTX108567-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

PACSIN1 blocking peptide - GTX89708-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Pig

PACSIN1 Immunizing peptide - orb15419 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PACSIN1 Blocking Peptide - 33R-3866 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PACSIN1 Peptide - AC21-0108-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PACSIN1 - H00029993-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PACSIN1 - H00029993-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PACSIN1 Peptide - 45-103P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

PACSIN1 fusion protein - Ag4102 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PACSIN1, His-tagged - PACSIN1-166H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human PACSIN1, GST-tagged - PACSIN1-1506H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Protein kinase C and casein kinase substrate in neurons protein 1(PACSIN1) - CSB-YP866312HU CSB-EP866312HU CSB-BP866312HU CSB-MP866312HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PACSIN1 - TP306626 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PACSIN1, Peptide - MBS425373 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Pig, Bovine

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