PACSIN1

Gene Symbol PACSIN1
Entrez Gene 29993
Alt Symbol SDPI
Species Human
Gene Type protein-coding
Description protein kinase C and casein kinase substrate in neurons 1
Other Description protein kinase C and casein kinase substrate in neurons protein 1|syndapin 1|syndapin I|syndapin-1
Swissprots Q9BY11 Q9P2G8
Accessions EAX03785 EAX03786 EAX03787 Q9BY11 AB037800 BAA92617 AF242529 AAK29206 AK289956 BAF82645 AK294132 BAG57460 AL834211 CAD38895 AM393510 CAL38387 BC040228 AAH40228 BC128219 AAI28220 BP211882 BP251080 DC312410 DQ892478 ABM83404 DQ895689 ABM86615 XM_011514541 XP_011512843 NM_001199583 NP_001186512 NM_020804 NP_065855
Function Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. {ECO:0000250}.
Tissue Specificity Highly expressed in brain and, at much lower levels, in heart and pancreas. {ECO:0000269|PubMed:11179684}.

Human-PACSIN1-cDNA-Clone - DC07336 from Abgent, a WuXi AppTec company

Prices $600.75
Sizes 10 µg
Species Human
Accession NM_020804

PACSIN1 cDNA (ANA00010-P001) - ANA00010-P001 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession NM_020804

PACSIN1 - MBS1270619 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC040228

Human PACSIN1 ORF Clone (BC040228) - CDCS409470 from Creative biogene

Species Human
Accession Q9BY11

Human PACSIN1 ORF clone (BC040228) - CDCB158670 from Creative biogene

Species Human
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