PACSIN1

Gene Symbol PACSIN1
Entrez Gene 29993
Alt Symbol SDPI
Species Human
Gene Type protein-coding
Description protein kinase C and casein kinase substrate in neurons 1
Other Description protein kinase C and casein kinase substrate in neurons protein 1|syndapin 1|syndapin I|syndapin-1
Swissprots Q9BY11 Q9P2G8
Accessions EAX03785 EAX03786 EAX03787 Q9BY11 AB037800 BAA92617 AF242529 AAK29206 AK289956 BAF82645 AK294132 BAG57460 AL834211 CAD38895 AM393510 CAL38387 BC040228 AAH40228 BC128219 AAI28220 BP211882 BP251080 DC312410 DQ892478 ABM83404 DQ895689 ABM86615 XM_011514541 XP_011512843 NM_001199583 NP_001186512 NM_020804 NP_065855
Function Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. {ECO:0000250}.
Tissue Specificity Highly expressed in brain and, at much lower levels, in heart and pancreas. {ECO:0000269|PubMed:11179684}.

PACSIN1 CRISPR/Cas9 KO Plasmid (h) - sc-404374 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN1 HDR Plasmid (h) - sc-404374-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN1 Double Nickase Plasmid (h) - sc-404374-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN1 Double Nickase Plasmid (h2) - sc-404374-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN1 CRISPR Activation Plasmid (h) - sc-404374-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN1 CRISPR Activation Plasmid (h2) - sc-404374-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN1 Lentiviral Activation Particles (h) - sc-404374-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN1 Lentiviral Activation Particles (h2) - sc-404374-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PACSIN1 siRNA (h) - sc-36171 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACSIN1 shRNA Plasmid (h) - sc-36171-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACSIN1 shRNA (h) Lentiviral Particles - sc-36171-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PACSIN1 RNAi - H00029993-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU120581 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16261 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16261 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11615 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11615

PACSIN1 siRNA (Human) - CRH9322 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PACSIN1 (NM_020804.4) - SHH369888 from Creative biogene

Category siRNA
Species Reactivities Human

Human PACSIN1 siRNA - orb269824 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PACSIN1 shRNA Plasmid (Human) - CHH9322 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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