Gene Symbol | CBLN1 |
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Entrez Gene | 869 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cerebellin 1 precursor |
Other Description | cerebellin-1|precerebellin |
Swissprots | P23435 B2RAN9 Q52M09 |
Accessions | EAW82731 P23435 AI147523 AK314276 BAG36936 BC093692 AAH93692 BC093718 AAH93718 CN281334 M58583 AAA35676 R50764 NM_004352 NP_004343 |
Function | Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. |
Tissue Specificity | In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des- Ser1]-cerebellin. |
Cerebellin 1 (F-14) - sc-164050 from Santa Cruz Biotechnology
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Anti-CBLN1 antibody - ab64184 from Abcam
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Anti-CBLN1 antibody - ab92526 from Abcam
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Anti-CBLN1 antibody [EPR13649] - ab181379 from Abcam
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Anti-CBLN1 antibody [EPR13655] - ab181219 from Abcam
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Anti-Precerebellin antibody - ab36908 from Abcam
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Anti-Precerebellin antibody - ab36909 from Abcam
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Anti-CBLN1 / Cerebellin 1 Antibody - LS-C121163 from LifeSpan Bioscience
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Anti-CBLN1 / Cerebellin 1 Antibody (aa148-193) - LS-C313705 from LifeSpan Bioscience
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Anti-CBLN1 / Cerebellin 1 Antibody (aa131-180) - LS-C119839 from LifeSpan Bioscience
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Anti-CBLN1 / Cerebellin 1 Antibody (C-Terminus) - LS-C135568 from LifeSpan Bioscience
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Anti-CBLN1 / Cerebellin 1 Antibody (C-Terminus) - LS-C19528 from LifeSpan Bioscience
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Anti-CBLN1 / Cerebellin 1 Antibody IHC-plus⢠- LS-B478 from LifeSpan Bioscience
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Cerebellin-1/Precerebellin Antibody - NBP1-77239 from Novus Biologicals
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Cerebellin-1/Precerebellin Antibody - NBP1-77238 from Novus Biologicals
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Cerebellin-1/Precerebellin Antibody - NBP1-68432 from Novus Biologicals
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CBLN1 Polyclonal Antibody - bs-11814R from Bioss
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Rabbit Anti-CBLN1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11814R-A350 from Bioss
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Rabbit Anti-CBLN1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11814R-A488 from Bioss
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Rabbit Anti-CBLN1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11814R-A555 from Bioss
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Rabbit Anti-CBLN1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11814R-A647 from Bioss
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Rabbit Anti-CBLN1 Polyclonal Antibody, Cy3 Conjugated - bs-11814R-Cy3 from Bioss
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Rabbit Anti-CBLN1 Polyclonal Antibody, Cy5 Conjugated - bs-11814R-Cy5 from Bioss
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Rabbit Anti-CBLN1 Polyclonal Antibody, Cy5.5 Conjugated - bs-11814R-Cy5.5 from Bioss
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Rabbit Anti-CBLN1 Polyclonal Antibody, Cy7 Conjugated - bs-11814R-Cy7 from Bioss
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