CBLN1

Gene Symbol CBLN1
Entrez Gene 869
Alt Symbol -
Species Human
Gene Type protein-coding
Description cerebellin 1 precursor
Other Description cerebellin-1|precerebellin
Swissprots P23435 B2RAN9 Q52M09
Accessions EAW82731 P23435 AI147523 AK314276 BAG36936 BC093692 AAH93692 BC093718 AAH93718 CN281334 M58583 AAA35676 R50764 NM_004352 NP_004343
Function Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). {ECO:0000250}.
Subcellular Location Secreted. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
Tissue Specificity In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des- Ser1]-cerebellin.

Cerebellin 1 CRISPR/Cas9 KO Plasmid (h) - sc-407032 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cerebellin 1 HDR Plasmid (h) - sc-407032-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cerebellin 1 Double Nickase Plasmid (h) - sc-407032-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cerebellin 1 Double Nickase Plasmid (h2) - sc-407032-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cerebellin 1 CRISPR Activation Plasmid (h) - sc-407032-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cerebellin 1 CRISPR Activation Plasmid (h2) - sc-407032-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cerebellin 1 Lentiviral Activation Particles (h) - sc-407032-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cerebellin 1 Lentiviral Activation Particles (h2) - sc-407032-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cerebellin 1 siRNA (h) - sc-93450 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cerebellin 1 shRNA Plasmid (h) - sc-93450-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cerebellin 1 shRNA (h) Lentiviral Particles - sc-93450-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU044281 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5412 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5412 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05166 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05166

CBLN1 siRNA (Human) - CRH0614 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CBLN1 - MBS8213415 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Cerebellin 1 CRISPR/Cas9 KO Plasmid (h2) - sc-407032-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cerebellin 1 HDR Plasmid (h2) - sc-407032-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human CBLN1 (NM_004352.3) - SHH255345 from Creative biogene

Category siRNA
Species Reactivities Human

CBLN1 shRNA Plasmid (Human) - CHH0614 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CBLN1 miRNA 3'UTR clone - MiUTR3H-03370 from Creative biogene

Species Reactivities Human
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