| Gene Symbol |
CBLN1
|
| Entrez Gene |
869
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cerebellin 1 precursor
|
| Other Description |
cerebellin-1|precerebellin
|
| Swissprots |
P23435 B2RAN9 Q52M09
|
| Accessions |
EAW82731 P23435 AI147523 AK314276 BAG36936 BC093692 AAH93692 BC093718 AAH93718 CN281334 M58583 AAA35676 R50764 NM_004352 NP_004343
|
| Function |
Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
|
| Tissue Specificity |
In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des- Ser1]-cerebellin.
|
![Western Blot: Precerebellin Overexpression Lysate (Adult Normal) [NBL1-08739] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Precerebellin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2996_Precerebellin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08739-img0002.jpg)