Gene Symbol | MDGA1 |
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Entrez Gene | 266727 |
Alt Symbol | GPIM, MAMDC3 |
Species | Human |
Gene Type | protein-coding |
Description | MAM domain containing glycosylphosphatidylinositol anchor 1 |
Other Description | GPI and MAM protein|MAM domain-containing glycosylphosphatidylinositol anchor protein 1|MAM domain-containing protein 3|glycosyl-phosphatidyl-inositol-MAM|glycosylphosphatidylinositol-MAM |
Swissprots | Q8NBE3 A6NHG0 Q8NFP4 |
Accessions | EAX03950 EAX03951 EAX03952 EAX03953 EAX03954 Q8NFP4 AF478693 AAM77220 AK055376 AK090677 BAC03502 AK091149 AK091650 AK092308 AK126965 BC152817 AAI52818 BC156659 AAI56660 BX647180 BX647253 XM_006715056 XP_006715119 XM_006715057 XP_006715120 XR_926140 XR_926141 XR_926142 NM_153487 NP_705691 |
Function | Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. {ECO:0000250, ECO:0000269|PubMed:23248271}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:15922729}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15922729}. Note=Associated with lipid rafts. |
Tissue Specificity | Has been found in brain, heart, skeletal muscle and kidney. Found to be overexpressed in tumor tissues. |
MDGA1 CRISPR/Cas9 KO Plasmid (h) - sc-406023 from Santa Cruz Biotechnology
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MDGA1 HDR Plasmid (h) - sc-406023-HDR from Santa Cruz Biotechnology
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MDGA1 Double Nickase Plasmid (h) - sc-406023-NIC from Santa Cruz Biotechnology
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MDGA1 Double Nickase Plasmid (h2) - sc-406023-NIC-2 from Santa Cruz Biotechnology
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MDGA1 CRISPR Activation Plasmid (h) - sc-406023-ACT from Santa Cruz Biotechnology
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MDGA1 CRISPR Activation Plasmid (h2) - sc-406023-ACT-2 from Santa Cruz Biotechnology
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MDGA1 Lentiviral Activation Particles (h) - sc-406023-LAC from Santa Cruz Biotechnology
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MDGA1 Lentiviral Activation Particles (h2) - sc-406023-LAC-2 from Santa Cruz Biotechnology
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MDGA1 siRNA (h) - sc-95567 from Santa Cruz Biotechnology
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MDGA1 shRNA Plasmid (h) - sc-95567-SH from Santa Cruz Biotechnology
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MDGA1 shRNA (h) Lentiviral Particles - sc-95567-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU012081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13138 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13138 from Sigma-Aldrich
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MDGA1 siRNA (Human) - CRJ6832 from Cohesion Biosciences
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shRNA set against Human MDGA1 (NM_153487.3) - SHH339591 from Creative biogene
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shRNA set against Human MDGA1(NM_153487.3) - SHH182333 from Creative biogene
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MDGA1 shRNA Plasmid (Human) - CHJ6832 from Cohesion Biosciences
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MDGA1 miRNA 3'UTR clone - MiUTR1H-06174 from Creative biogene
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