| Gene Symbol |
FBXL21
|
| Entrez Gene |
26223
|
| Alt Symbol |
FBL3B, FBXL3B, FBXL3P, Fbl21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and leucine-rich repeat protein 21 (gene/pseudogene)
|
| Other Description |
F-box and leucine-rich repeat protein 3 pseudogene|F-box and leucine-rich repeat protein 3B|F-box protein Fbl3b|F-box/LRR-repeat protein 21|F-box/LRR-repeat protein 3B
|
| Swissprots |
Q9UKT6
|
| Accessions |
EAW62202 EAW62203 Q9UKT6 AF129533 AAF04467 BC044938 BC106753 AAI06754 DA633926 NM_012159 NP_036291
|
| Function |
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity). {ECO:0000250}.
|