FBXL21

Gene Symbol	FBXL21
Entrez Gene	26223
Alt Symbol	FBL3B, FBXL3B, FBXL3P, Fbl21
Species	Human
Gene Type	protein-coding
Description	F-box and leucine-rich repeat protein 21 (gene/pseudogene)
Other Description	F-box and leucine-rich repeat protein 3 pseudogene|F-box and leucine-rich repeat protein 3B|F-box protein Fbl3b|F-box/LRR-repeat protein 21|F-box/LRR-repeat protein 3B
Swissprots	Q9UKT6
Accessions	EAW62202 EAW62203 Q9UKT6 AF129533 AAF04467 BC044938 BC106753 AAI06754 DA633926 NM_012159 NP_036291
Function	Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBXL21 full length protein - ab161927 from Abcam Category Protein Source Wheat germ Species Human

Human FBXL21 protein fragment - ab161928 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human FBXL21 Protein - H00026223-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human FBXL21 Protein - H00026223-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FBXL21 - H00026223-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FBXL21 - H00026223-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FBXL21 - H00026223-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FBXL21 - H00026223-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FBXL21 fusion protein - ag16049 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

FBXL21 fusion protein - Ag17343 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human FBXL21, His-tagged - FBXL21-12779H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human F-box/LRR-repeat protein 21(FBXL21) - CSB-YP891953HU CSB-EP891953HU CSB-BP891953HU CSB-MP891953HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FBXL21 Peptide, Human - M34GP05576H from Creative Peptides Category Peptide Source Synthetic. Species Human

F-box/LRR-repeat protein 21 (FBXL21), Recombinant Protein - MBS1306530 from MyBioSource Category Protein Prices $1,210.00, $1,210.00, $1,430.00, $1,430.00, $1,960.00, $1,960.00, $2,425.00, $2,425.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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