FBXL21

Gene Symbol FBXL21
Entrez Gene 26223
Alt Symbol FBL3B, FBXL3B, FBXL3P, Fbl21
Species Human
Gene Type protein-coding
Description F-box and leucine-rich repeat protein 21 (gene/pseudogene)
Other Description F-box and leucine-rich repeat protein 3 pseudogene|F-box and leucine-rich repeat protein 3B|F-box protein Fbl3b|F-box/LRR-repeat protein 21|F-box/LRR-repeat protein 3B
Swissprots Q9UKT6
Accessions EAW62202 EAW62203 Q9UKT6 AF129533 AAF04467 BC044938 BC106753 AAI06754 DA633926 NM_012159 NP_036291
Function Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity). {ECO:0000250}.

FBL3B CRISPR/Cas9 KO Plasmid (h) - sc-405317 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3B HDR Plasmid (h) - sc-405317-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3B Double Nickase Plasmid (h) - sc-405317-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3B Double Nickase Plasmid (h2) - sc-405317-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3B CRISPR Activation Plasmid (h) - sc-405317-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3B CRISPR Activation Plasmid (h2) - sc-405317-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3B Lentiviral Activation Particles (h) - sc-405317-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3B Lentiviral Activation Particles (h2) - sc-405317-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL3B siRNA (h) - sc-62298 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL3B shRNA Plasmid (h) - sc-62298-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL3B shRNA (h) Lentiviral Particles - sc-62298-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBXL21 RNAi - H00026223-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU096411 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU089101 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8524 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8524 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FBXL21 siRNA (Human) - CRH8760 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBXL21 - MBS8233067 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FBXL21 (NM_012159.4) - SHH292933 from Creative biogene

Category siRNA
Species Reactivities Human

Human FBXL21 siRNA - orb269262 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBXL21 shRNA Plasmid (Human) - CHH8760 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FBXL21 miRNA 3'UTR clone - MiUTR4H-TG03469 from Creative biogene

Species Reactivities Human
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