| Gene Symbol |
LRRC4
|
| Entrez Gene |
64101
|
| Alt Symbol |
NAG14, NGL-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 4
|
| Other Description |
brain tumor associated protein LRRC4|brain tumor-associated protein BAG|leucine-rich repeat-containing 4|leucine-rich repeat-containing protein 4|nasopharyngeal carcinoma-associated gene 14 protein|netrin-G2 ligand
|
| Swissprots |
Q6ZMI8 Q9HBW1 Q14DU9 Q96A85 A4D0Y9
|
| Accessions |
EAL24316 EAW83639 Q9HBW1 AF196976 AAG28019 AI568859 AJ297858 CAC82651 AK172751 BAD18737 AK314047 BAG36756 AY358307 AAQ88674 BC036685 BC111561 AAI11562 BC111745 AAI11746 BU682120 XM_011516461 XP_011514763 NM_022143 NP_071426
|
| Function |
Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=LRRC4 and DLG4 are interdependent for synaptic localization. {ECO:0000250}.
|
| Tissue Specificity |
Specifically expressed in brain. {ECO:0000269|PubMed:15967442}.
|
| Top Pathways |
Axon guidance, Cell adhesion molecules (CAMs)
|