Gene Symbol | SNRPD2 |
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Entrez Gene | 6633 |
Alt Symbol | SMD2, SNRPD1, Sm-D2 |
Species | Human |
Gene Type | protein-coding |
Description | small nuclear ribonucleoprotein D2 polypeptide 16.5kDa |
Other Description | small nuclear ribonucleoprotein Sm D2|snRNP core protein D2 |
Swissprots | J3KPM5 P62316 A8K797 |
Accessions | AAD22673 CAE94072 EAW57373 EAW57374 P62316 AJ707552 AK291912 BAF84601 BC000486 AAH00486 BC001930 AAH01930 BG528418 BU532756 CB136390 DA325073 DQ891246 ABM82172 DQ894432 ABM85358 U15008 AAC13776 XM_005259180 XP_005259237 NM_004597 NP_004588 NM_177542 NP_808210 |
Function | Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. |
Top Pathways | Spliceosome |
Sm D2 CRISPR/Cas9 KO Plasmid (h) - sc-411015 from Santa Cruz Biotechnology
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Sm D2 HDR Plasmid (h) - sc-411015-HDR from Santa Cruz Biotechnology
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Sm D2 Double Nickase Plasmid (h) - sc-411015-NIC from Santa Cruz Biotechnology
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Sm D2 Double Nickase Plasmid (h2) - sc-411015-NIC-2 from Santa Cruz Biotechnology
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Sm D2 CRISPR Activation Plasmid (h) - sc-411015-ACT from Santa Cruz Biotechnology
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Sm D2 CRISPR Activation Plasmid (h2) - sc-411015-ACT-2 from Santa Cruz Biotechnology
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Sm D2 Lentiviral Activation Particles (h) - sc-411015-LAC from Santa Cruz Biotechnology
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Sm D2 Lentiviral Activation Particles (h2) - sc-411015-LAC-2 from Santa Cruz Biotechnology
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Sm D2 siRNA (h) - sc-97801 from Santa Cruz Biotechnology
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Sm D2 shRNA Plasmid (h) - sc-97801-SH from Santa Cruz Biotechnology
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Sm D2 shRNA (h) Lentiviral Particles - sc-97801-V from Santa Cruz Biotechnology
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SNRPD2 RNAi - H00006633-R02 from Novus Biologicals
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SNRPD2 RNAi - H00006633-R01 from Novus Biologicals
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MISSION® esiRNA - EHU146751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20271 from Sigma-Aldrich
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SNRPD2 siRNA (Human) - CRH4515 from Cohesion Biosciences
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SNRPD2 - MBS8228144 from MyBioSource
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shRNA set against Human SNRPD2 (NM_177542.2) - SHH414376 from Creative biogene
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Human SNRPD2 siRNA - orb265017 from Biorbyt
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SNRPD2 shRNA Plasmid (Human) - CHH4515 from Cohesion Biosciences
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SNRPD2 miRNA 3'UTR clone - MiUTR3H-03851 from Creative biogene
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SNRPD2 miRNA 3'UTR clone - MiUTR3H-03852 from Creative biogene
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