| Gene Symbol |
PGAP3
|
| Entrez Gene |
93210
|
| Alt Symbol |
AGLA546, CAB2, PERLD1, PP1498, hCOS16
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
post-GPI attachment to proteins 3
|
| Other Description |
COS16 homolog|gene coamplified with ERBB2 protein|per1-like domain containing 1|post-GPI attachment to proteins factor 3
|
| Swissprots |
Q86Z03 Q96FM1 Q8NBJ8 B4DGK7
|
| Accessions |
EAW60589 EAW60590 EAW60591 EAW60592 EAW60593 EAW60594 Q96FM1 AB088396 BAC55580 AF217980 AAG17223 AK057911 AK075473 AK075474 BAC11642 AK289612 BAF82301 AK294639 BAG57818 AK301106 BAG62705 AK314469 AL833198 AY358437 AAQ88803 BC010652 AAH10652 BG472165 DC389056 XM_011525480 XP_011523782 XM_011525481 XP_011523783 XR_934601 NM_001291726 NP_001278655 NM_001291728 NP_001278657 NM_001291730 NP_001278659 NM_001291732 NP_001278661 NM_001291733 NP_001278662 NM_033419 NP_219487
|
| Function |
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable). {ECO:0000305|PubMed:17021251}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305|PubMed:12460457}; Multi-pass membrane protein {ECO:0000305|PubMed:12460457}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:12460457}; Multi-pass membrane protein {ECO:0000305|PubMed:12460457}. Note=Mainly localizes to Golgi apparatus. {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitously expressed, with highest levels in thyroid and placenta. {ECO:0000269|PubMed:12460457}.
|
![Western Blot: PGAP3 Overexpression Lysate (Adult Normal) [NBP2-05879] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PGAP3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6345_PGAP3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05879-img0001.jpg)