Gene Symbol | PGAP3 |
---|---|
Entrez Gene | 93210 |
Alt Symbol | AGLA546, CAB2, PERLD1, PP1498, hCOS16 |
Species | Human |
Gene Type | protein-coding |
Description | post-GPI attachment to proteins 3 |
Other Description | COS16 homolog|gene coamplified with ERBB2 protein|per1-like domain containing 1|post-GPI attachment to proteins factor 3 |
Swissprots | Q86Z03 Q96FM1 Q8NBJ8 B4DGK7 |
Accessions | EAW60589 EAW60590 EAW60591 EAW60592 EAW60593 EAW60594 Q96FM1 AB088396 BAC55580 AF217980 AAG17223 AK057911 AK075473 AK075474 BAC11642 AK289612 BAF82301 AK294639 BAG57818 AK301106 BAG62705 AK314469 AL833198 AY358437 AAQ88803 BC010652 AAH10652 BG472165 DC389056 XM_011525480 XP_011523782 XM_011525481 XP_011523783 XR_934601 NM_001291726 NP_001278655 NM_001291728 NP_001278657 NM_001291730 NP_001278659 NM_001291732 NP_001278661 NM_001291733 NP_001278662 NM_033419 NP_219487 |
Function | Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable). {ECO:0000305|PubMed:17021251}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305|PubMed:12460457}; Multi-pass membrane protein {ECO:0000305|PubMed:12460457}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:12460457}; Multi-pass membrane protein {ECO:0000305|PubMed:12460457}. Note=Mainly localizes to Golgi apparatus. {ECO:0000305}. |
Tissue Specificity | Ubiquitously expressed, with highest levels in thyroid and placenta. {ECO:0000269|PubMed:12460457}. |
PERLD1 CRISPR/Cas9 KO Plasmid (h) - sc-413968 from Santa Cruz Biotechnology
|
||||||||
PERLD1 HDR Plasmid (h) - sc-413968-HDR from Santa Cruz Biotechnology
|
||||||||
PERLD1 Double Nickase Plasmid (h) - sc-413968-NIC from Santa Cruz Biotechnology
|
||||||||
PERLD1 Double Nickase Plasmid (h2) - sc-413968-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PERLD1 CRISPR Activation Plasmid (h) - sc-413968-ACT from Santa Cruz Biotechnology
|
||||||||
PERLD1 CRISPR Activation Plasmid (h2) - sc-413968-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PERLD1 Lentiviral Activation Particles (h) - sc-413968-LAC from Santa Cruz Biotechnology
|
||||||||
PERLD1 Lentiviral Activation Particles (h2) - sc-413968-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PERLD1 siRNA (h) - sc-93635 from Santa Cruz Biotechnology
|
||||||||
PERLD1 shRNA Plasmid (h) - sc-93635-SH from Santa Cruz Biotechnology
|
||||||||
PERLD1 shRNA (h) Lentiviral Particles - sc-93635-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU063041 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN16674 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16674 from Sigma-Aldrich
|
||||||||
PGAP3 siRNA (Human) - CRJ4198 from Cohesion Biosciences
|
||||||||
shRNA set against Human PGA (NM_033419.3) - SHH374056 from Creative biogene
|
||||||||
shRNA set against Human PERLD1(NM_033419.3) - SHR095272 from Creative biogene
|
||||||||
PGAP3 shRNA Plasmid (Human) - CHJ4198 from Cohesion Biosciences
|
||||||||
PGAP3 miRNA 3'UTR clone - MiUTR1H-07787 from Creative biogene
|