| Gene Symbol |
STEAP4
|
| Entrez Gene |
79689
|
| Alt Symbol |
STAMP2, TIARP, TNFAIP9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
STEAP family member 4
|
| Other Description |
metalloreductase STEAP4|six transmembrane prostate protein 2|six-transmembrane epithelial antigen of prostate 4|sixTransMembrane protein of prostate 2|tumor necrosis factor, alpha-induced protein 9|tumor necrosis-alpha-induced adipose-related protein
|
| Swissprots |
Q8WWB0 Q687X4 Q658Q9 Q9H5R1 Q687X5
|
| Accessions |
CAJ55791 CAJ90615 CAK32295 EAW76906 EAW76907 Q687X5 AF423422 AAQ04063 AF423423 AAQ04064 AK026806 BAB15559 AK027807 AK307644 AL832955 AL833044 CAH56271 AL833671 BC020600 AAH20600 DA977808 DB162772 DC333286 NM_001205315 NP_001192244 NM_001205316 NP_001192245 NM_024636 NP_078912
|
| Function |
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. {ECO:0000250, ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367, ECO:0000269|PubMed:19660107, ECO:0000269|PubMed:19787193}.
|
| Subcellular Location |
Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages. {ECO:0000269|PubMed:15897894, ECO:0000269|PubMed:16227996, ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367, ECO:0000269|PubMed:19289123, ECO:0000269|PubMed:19660107}.
|