| Gene Symbol |
MARCH4
|
| Entrez Gene |
57574
|
| Alt Symbol |
MARCH-IV, RNF174
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase MARCH4|RING finger protein 174|membrane-associated RING finger protein 4|membrane-associated RING-CH protein IV
|
| Swissprots |
Q4KMN7 Q9P2E8 Q86WR8
|
| Accessions |
EAW70566 Q9P2E8 AB037820 BAA92637 AL353945 AW051292 BC048793 AAH48793 BC098448 AAH98448 EU832625 ACE87716 EU832698 ACE87030 U79281 XM_011511523 XP_011509825 NM_020814 NP_065865
|
| Function |
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14722266}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000269|PubMed:14722266}.
|
| Tissue Specificity |
Expressed in brain and placenta. {ECO:0000269|PubMed:14722266}.
|