MARCH4

Gene Symbol	MARCH4
Entrez Gene	57574
Alt Symbol	MARCH-IV, RNF174
Species	Human
Gene Type	protein-coding
Description	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MARCH4|RING finger protein 174|membrane-associated RING finger protein 4|membrane-associated RING-CH protein IV
Swissprots	Q4KMN7 Q9P2E8 Q86WR8
Accessions	EAW70566 Q9P2E8 AB037820 BAA92637 AL353945 AW051292 BC048793 AAH48793 BC098448 AAH98448 EU832625 ACE87716 EU832698 ACE87030 U79281 XM_011511523 XP_011509825 NM_020814 NP_065865
Function	E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269|PubMed:14722266}.
Subcellular Location	Golgi apparatus membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000269|PubMed:14722266}.
Tissue Specificity	Expressed in brain and placenta. {ECO:0000269|PubMed:14722266}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MARCH4 protein fragment - ab163594 from Abcam Category Protein Source Wheat germ Species Human

RNF174 / MARCH4 Antibody Blocking Peptide - LS-E2365 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF174 / MARCH4 Antibody Blocking Peptide - LS-E15926 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF174 / MARCH4 Antibody Blocking Peptide - LS-E26596 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MARCH4 Protein - H00057574-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MARCH4-Antibody-C-term-Blocking-peptide - BP13332b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MARCH4 blocking peptide - GTX88857-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

MARCH IV Immunizing peptide - orb17782 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

RNF174 Blocking Peptide - 33R-3405 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MARCH4 Peptide - AC21-1432-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MARCH4 / RNF174 - H00057574-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MARCH4 / RNF174 - H00057574-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MARCH4 Peptide - 46-685P from ProSci Category Peptide

MARCH-IV, Peptide - MBS426372 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

MARCH4, Peptide - MBS658530 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg Species Human

MARCH4 Peptide, Human - M34GP09226H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase MARCH4 (MARCH4), Recombinant Protein - MBS7006875 from MyBioSource Category Protein Prices $1,200.00, $2,185.00, $3,390.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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