| Gene Symbol |
ATF6
|
| Entrez Gene |
22926
|
| Alt Symbol |
ATF6A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
activating transcription factor 6
|
| Other Description |
cAMP-dependent transcription factor ATF-6 alpha|cyclic AMP-dependent transcription factor ATF-6 alpha
|
| Swissprots |
O15139 Q5VW62 Q9UEC9 Q6IPB5 P18850
|
| Accessions |
EAW90694 P18850 AB015856 BAA34722 AB208929 BAD92166 AF005887 AAB64434 AF088035 AK025316 AK290498 BAF83187 BC014969 AAH14969 BC071997 AAH71997 BC166676 AAI66676 BM683233 BP380917 BX538263 XM_006711224 XP_006711287 XM_011509308 XP_011507610 XM_011509309 XP_011507611 XM_011509310 XP_011507612 NM_007348 NP_031374
|
| Function |
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. {ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Alzheimer's disease, Protein processing in endoplasmic reticulum
|