ATF6

Gene Symbol ATF6
Entrez Gene 22926
Alt Symbol ATF6A
Species Human
Gene Type protein-coding
Description activating transcription factor 6
Other Description cAMP-dependent transcription factor ATF-6 alpha|cyclic AMP-dependent transcription factor ATF-6 alpha
Swissprots O15139 Q5VW62 Q9UEC9 Q6IPB5 P18850
Accessions EAW90694 P18850 AB015856 BAA34722 AB208929 BAD92166 AF005887 AAB64434 AF088035 AK025316 AK290498 BAF83187 BC014969 AAH14969 BC071997 AAH71997 BC166676 AAI66676 BM683233 BP380917 BX538263 XM_006711224 XP_006711287 XM_011509308 XP_011507610 XM_011509309 XP_011507611 XM_011509310 XP_011507612 NM_007348 NP_031374
Function Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. {ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue Specificity Ubiquitous.
Top Pathways Alzheimer's disease, Protein processing in endoplasmic reticulum

ATF-6α (C-18) - sc-14253 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ATF-6α (C-18): sc-14253. Western blot analysis of ATF-6α expression in MCF7 nuclear extract.

ATF-6α (F-7) - sc-166659 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ATF-6α (F-7): sc-166659. Western blot analysis of ATF-6α expression in c4 whole cell lysate (A) and rat liver tissue extract (B).

ATF-6α (H-280) - sc-22799 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ATF-6α (H-280): sc-22799. Western blot analysis of ATF-6α expression in MCF7 nuclear extract.

ATF-6α (N-16) - sc-14250 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ATF-6α (N-16): sc-14250. Western blot analysis of ATF-6α expression in MCF7 nuclear extract.

Anti-ATF6 antibody - ab37149 from Abcam

Host Rabbit
Clonality Polyclonal
ab37149 staining human Hella cells by ICC/IF. Cells were PFA fixed and permeabilized for 10 minutes in 0.1% Triton X-100 prior to blocking in 3% BSA for 15 minutes at 25°C. The primary antibody was diluted 1/200 and incubated with the sample for 1 hour. The secondary antibody used was Alexa Fluor®568 goat anti-rabbit (ab175471) diluted at 1/1000.See Abreview

Anti-ATF6 antibody - ab135707 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ATF6 antibody (ab135707) at 1/100 dilution + A2058 cell line lysates at 35 µg

Anti-ATF6 antibody - ab203119 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded rat brain tissue sections labeling ATF6 with ab203119 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-ATF6 antibody - ab83504 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ATF6 antibody (ab83504) at 1 µg/ml + MDA-MB-361 (Human breast adenocarcinoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-ATF6 antibody - ab134561 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ATF6 antibody (ab134561) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-ATF6 antibody - ab174756 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-ATF6 antibody (ab174756) at 2 µg/ml + HeLa lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-ATF6 antibody [1-7] - ab122897 from Abcam

Prices $398.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1-7
All lanes : Anti-ATF6 antibody [1-7] (ab122897) at 1/500 dilutionLane 1 : 293T cell lysate: controlLane 2 : 293T cell lysate: treated with 2 µg/ml tunicamycin for 7 hoursLane 3 : 293T cell lysate: treated with 1mM DTT for 1 hour.Lane 4 : HeLa S3 Tet-off cell lysate: controlLane 5 : HeLa S3 Tet-off cell lysate: treated with 1mM DTT for 1 hour.

Anti-ATF6 antibody [70B1413] - ChIP Grade - ab11909 from Abcam

Host Mouse
Clonality Monoclonal
Clone 70B1413
ICC/IF image of ab11909 stained MCF7 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab11909, 10µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-mouse IgG (H+L) ab150113) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-ATF6 antibody - Carboxyterminal end - ab62576 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62576 at 10µg/ml staining AFT6 in MCF7 cells by Immunocytochemistry.

Anti-ATF6 Antibody (aa1-273, clone 70B1413.1) IHC-plus™ - LS-B2564 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 70B1413.1
Anti-ATF6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2564 concentration 10 ug/ml.

Anti-ATF6 Antibody (C-Terminus) IHC-plus™ - LS-B2516 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ATF6 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2516 concentration 5 ug/ml.

Anti-ATF6 Antibody - LS-C330827 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat spleen using ATF6 antibody at dilution of 1:200 (200x lens).

Anti-ATF6 Antibody (C-Terminus) - LS-C3517 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ATF6 Antibody (aa635-647) - LS-C148046 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-ATF6 Antibody (aa491-509) - LS-C148049 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATF6 Antibody (N-Terminus, Magnetic beads) - LS-C171662 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ATF6 Antibody (N-Terminus, Sepharose) - LS-C171663 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ATF6 Antibody (aa36-85) - LS-C109612 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ATF6 antibody LS-C109612 Western blot of HeLa lysate.

Anti-ATF6 Antibody - LS-C136870 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATF6 Antibody (clone 3D5) IHC-plus™ - LS-B6032 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3D5
Anti-ATF6 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6032 concentration 10 ug/ml.

Anti-ATF6 Antibody (Biotin) - LS-C180692 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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