| Gene Symbol |
LAMC2
|
| Entrez Gene |
3918
|
| Alt Symbol |
B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
laminin, gamma 2
|
| Other Description |
BM600-100kDa|CSF 140 kDa subunit|cell-scattering factor 140 kDa subunit|epiligrin subunit gamma|kalinin subunit gamma|ladsin 140 kDa subunit|laminin B2t chain|laminin subunit gamma-2|large adhesive scatter factor 140 kDa subunit|nicein subunit gamma
|
| Swissprots |
Q02536 Q14941 Q13752 Q2M1N2 Q5VYE8 Q13753 Q02537 Q14DF7
|
| Accessions |
AAC50456 AAC50457 EAW91146 EAW91147 Q13753 AK296944 BAG59493 AK307945 BC112286 AAI12287 BC113378 AAI13379 BC143653 X73902 CAA52108 Z15008 CAA78728 Z15009 CAA78729 NM_005562 NP_005553 NM_018891 NP_061486
|
| Function |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. {ECO:0000269|PubMed:8265624}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
|
| Tissue Specificity |
The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Toxoplasmosis
|