Gene Symbol | LAMC2 |
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Entrez Gene | 3918 |
Alt Symbol | B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2 |
Species | Human |
Gene Type | protein-coding |
Description | laminin, gamma 2 |
Other Description | BM600-100kDa|CSF 140 kDa subunit|cell-scattering factor 140 kDa subunit|epiligrin subunit gamma|kalinin subunit gamma|ladsin 140 kDa subunit|laminin B2t chain|laminin subunit gamma-2|large adhesive scatter factor 140 kDa subunit|nicein subunit gamma |
Swissprots | Q02536 Q14941 Q13752 Q2M1N2 Q5VYE8 Q13753 Q02537 Q14DF7 |
Accessions | AAC50456 AAC50457 EAW91146 EAW91147 Q13753 AK296944 BAG59493 AK307945 BC112286 AAI12287 BC113378 AAI13379 BC143653 X73902 CAA52108 Z15008 CAA78728 Z15009 CAA78729 NM_005562 NP_005553 NM_018891 NP_061486 |
Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. {ECO:0000269|PubMed:8265624}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. |
Tissue Specificity | The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli. |
Top Pathways | Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Toxoplasmosis |
Laminin γ-2 CRISPR/Cas9 KO Plasmid (h) - sc-401068 from Santa Cruz Biotechnology
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Laminin γ-2 HDR Plasmid (h) - sc-401068-HDR from Santa Cruz Biotechnology
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Laminin γ-2 Double Nickase Plasmid (h) - sc-401068-NIC from Santa Cruz Biotechnology
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Laminin γ-2 Double Nickase Plasmid (h2) - sc-401068-NIC-2 from Santa Cruz Biotechnology
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Laminin γ-2 CRISPR Activation Plasmid (h) - sc-401068-ACT from Santa Cruz Biotechnology
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Laminin γ-2 CRISPR Activation Plasmid (h2) - sc-401068-ACT-2 from Santa Cruz Biotechnology
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Laminin γ-2 Lentiviral Activation Particles (h) - sc-401068-LAC from Santa Cruz Biotechnology
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Laminin γ-2 Lentiviral Activation Particles (h2) - sc-401068-LAC-2 from Santa Cruz Biotechnology
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Laminin γ-2 siRNA (h) - sc-35782 from Santa Cruz Biotechnology
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Laminin γ-2 shRNA Plasmid (h) - sc-35782-SH from Santa Cruz Biotechnology
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Laminin γ-2 shRNA (h) Lentiviral Particles - sc-35782-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU023131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11537 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11537 from Sigma-Aldrich
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LAMC2 siRNA (Human) - CRH2656 from Cohesion Biosciences
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Laminin γ-2 CRISPR/Cas9 KO Plasmid (h2) - sc-401068-KO-2 from Santa Cruz Biotechnology
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Laminin γ-2 HDR Plasmid (h2) - sc-401068-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human LAMC2 (NM_005562.2) - SHH328311 from Creative biogene
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shRNA set against Human LAMC2(NM_005562.2) - SHH141671 from Creative biogene
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shRNA set against Human LAMC2(NM_018891.2) - SHH141707 from Creative biogene
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Human LAMC2 siRNA - orb263158 from Biorbyt
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LAMC2 shRNA Plasmid (Human) - CHH2656 from Cohesion Biosciences
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LAMC2 miRNA 3'UTR clone - MiUTR1H-05564 from Creative biogene
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LAMC2 miRNA 3'UTR clone - MiUTR1H-05565 from Creative biogene
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