Gene Symbol | STAT5B |
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Entrez Gene | 6777 |
Alt Symbol | STAT5 |
Species | Human |
Gene Type | protein-coding |
Description | signal transducer and activator of transcription 5B |
Other Description | transcription factor STAT5B |
Swissprots | P51692 Q8WWS8 |
Accessions | CAD19638 CAG32954 EAW60817 P51692 AB208920 BAD92157 AK308163 AL040162 AL080218 BC020868 AAH20868 BC029072 BC065227 AAH65227 EU446501 ABZ92030 U47686 AAC50491 U48730 AAC50485 XM_005257625 XP_005257682 XM_005257626 XP_005257683 NM_012448 NP_036580 |
Function | Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. {ECO:0000269|PubMed:11773439}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000250}. |
Top Pathways | Chemokine signaling pathway, Prolactin signaling pathway, Viral carcinogenesis, Measles, HTLV-I infection |
Stat5b CRISPR/Cas9 KO Plasmid (h) - sc-400878 from Santa Cruz Biotechnology
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Stat5b HDR Plasmid (h) - sc-400878-HDR from Santa Cruz Biotechnology
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Stat5b Double Nickase Plasmid (h) - sc-400878-NIC from Santa Cruz Biotechnology
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Stat5b Double Nickase Plasmid (h2) - sc-400878-NIC-2 from Santa Cruz Biotechnology
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Stat5b CRISPR Activation Plasmid (h) - sc-400878-ACT from Santa Cruz Biotechnology
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Stat5b CRISPR Activation Plasmid (h2) - sc-400878-ACT-2 from Santa Cruz Biotechnology
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Stat5b Lentiviral Activation Particles (h) - sc-400878-LAC from Santa Cruz Biotechnology
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Stat5b Lentiviral Activation Particles (h2) - sc-400878-LAC-2 from Santa Cruz Biotechnology
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Stat5b siRNA (h) - sc-37010 from Santa Cruz Biotechnology
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Stat5b shRNA Plasmid (h) - sc-37010-SH from Santa Cruz Biotechnology
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Stat5b shRNA (h) Lentiviral Particles - sc-37010-V from Santa Cruz Biotechnology
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STAT5b RNAi - H00006777-R01 from Novus Biologicals
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MISSION® esiRNA - EHU036651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20712 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20712 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11609 from Sigma-Aldrich
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STAT5B siRNA (Human) - CRH4634 from Cohesion Biosciences
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STAT5B - MBS8233886 from MyBioSource
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shRNA set against Human STAT5B (NM_012448.3) - SHH419444 from Creative biogene
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shRNA set against Human STAT5B(NM_012448.3) - SHL040350 from Creative biogene
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Human STAT5B siRNA - orb265136 from Biorbyt
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STAT5B shRNA Plasmid (Human) - CHH4634 from Cohesion Biosciences
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STAT5B miRNA 3'UTR clone - MiUTR1H-09982 from Creative biogene
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