| Gene Symbol |
GLRX2
|
| Entrez Gene |
51022
|
| Alt Symbol |
CGI-133, GRX2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutaredoxin 2
|
| Other Description |
bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2)
|
| Swissprots |
Q9NS18 Q9Y3D4 Q3LR69 Q96JC0 Q7L1N7
|
| Accessions |
ABA03170 CBF61391 CBF61398 CBF61800 CBF61807 CBF64885 CBF64892 CBF65449 CBF65456 CBF69768 CBF69783 CBF71621 CBF71635 CBF72937 CBF72952 CBF74264 CBF74280 CBF82314 CBF82330 CBU86419 CBU86426 CBU86676 CBU86683 CBU89756 CBU89763 CBU90320 CBU90327 CBU94419 CBU94426 CBU95298 CBU95305 CBU95927 CBU95934 CBU96576 CBU96583 CBV00324 CBV00331 EAW91248 EAW91249 Q9NS18 AA056513 AA887118 AF132495 AAF37320 AF151891 AAD34128 AF290514 AAK83089 AY038988 AAK72499 BC009669 AAH09669 BC028113 AAH28113 BQ432881 BU157087 CN362908 XM_005245231 XP_005245288 NM_001243399 NP_001230328 NM_016066 NP_057150 NM_197962 NP_932066
|
| Function |
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:14676218, ECO:0000269|PubMed:15328416, ECO:0000269|PubMed:15649413}.
|
| Subcellular Location |
Isoform 1: Mitochondrion.
|
| Tissue Specificity |
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:15184054, ECO:0000269|PubMed:15297967}.
|