GLRX2

Gene Symbol GLRX2
Entrez Gene 51022
Alt Symbol CGI-133, GRX2
Species Human
Gene Type protein-coding
Description glutaredoxin 2
Other Description bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2)
Swissprots Q9NS18 Q9Y3D4 Q3LR69 Q96JC0 Q7L1N7
Accessions ABA03170 CBF61391 CBF61398 CBF61800 CBF61807 CBF64885 CBF64892 CBF65449 CBF65456 CBF69768 CBF69783 CBF71621 CBF71635 CBF72937 CBF72952 CBF74264 CBF74280 CBF82314 CBF82330 CBU86419 CBU86426 CBU86676 CBU86683 CBU89756 CBU89763 CBU90320 CBU90327 CBU94419 CBU94426 CBU95298 CBU95305 CBU95927 CBU95934 CBU96576 CBU96583 CBV00324 CBV00331 EAW91248 EAW91249 Q9NS18 AA056513 AA887118 AF132495 AAF37320 AF151891 AAD34128 AF290514 AAK83089 AY038988 AAK72499 BC009669 AAH09669 BC028113 AAH28113 BQ432881 BU157087 CN362908 XM_005245231 XP_005245288 NM_001243399 NP_001230328 NM_016066 NP_057150 NM_197962 NP_932066
Function Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:14676218, ECO:0000269|PubMed:15328416, ECO:0000269|PubMed:15649413}.
Subcellular Location Isoform 1: Mitochondrion.
Tissue Specificity Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:15184054, ECO:0000269|PubMed:15297967}.

Anti-Glutaredoxin 2 antibody - ab167207 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Glutaredoxin 2 antibody (ab167207) at 1 µg/mlLane 1 : Lysate from 293T cells transfected with Glutaredoxin 2Lane 2 : 293T cell lysate Non-transfectedLysates/proteins at 15 µg per lane.

Anti-Glutaredoxin 2 antibody [1A3] - ab16733 from Abcam

Prices $359.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A3

Anti-Glutaredoxin 2 antibody - C-terminal - ab85267 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Glutaredoxin 2 antibody - C-terminal (ab85267) at 1/50 dilution + mouse cerebellum tissue lysates at 35 µg

Anti-GLRX2 / Glutaredoxin 2 Antibody (aa120-146) - LS-C100887 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain reacted with GLRX2 Antibody (C-term T135), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-GLRX2 / Glutaredoxin 2 Antibody (aa103-119) - LS-C313022 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
GLRX2 / Glutaredoxin 2 antibody. IHC(P): Rat Brain Tissue.

Anti-GLRX2 / Glutaredoxin 2 Antibody - LS-C129309 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GLRX2 / Glutaredoxin 2 Antibody - LS-C308079 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-GLRX2 / Glutaredoxin 2 Antibody - LS-C308081 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GLRX2 / Glutaredoxin 2 Antibody (aa91-141) - LS-C117035 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GLRX2 antibody LS-C117035 Western blot of Fetal Heart lysate.

Glutaredoxin 2 Antibody - NBP1-79689 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Glutaredoxin 2 Antibody [NBP1-79689] - Human Heart lysate, concentration 0.2-1 ug/ml.

Glutaredoxin 2 Antibody - NBP1-90040 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Glutaredoxin 2 Antibody [NBP1-90040] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.

Glutaredoxin 2 Antibody - H00051022-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Glutaredoxin 2 Antibody [H00051022-B01P] - Analysis of GLRX2 expression in transfected 293T cell line by GLRX2 polyclonal antibody. Lane 1: GLRX2 transfected lysate(13.75 KDa). Lane 2: Non-transfected lysate.

Glutaredoxin 2 Antibody - NBP2-34827 from Novus Biologicals

Prices $429.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Antibody - H00051022-B02P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Glutaredoxin 2 Antibody [H00051022-B02P] - Analysis of GLRX2 expression in transfected 293T cell line by GLRX2 polyclonal antibody. Lane 1: GLRX2 transfected lysate(18.04 KDa). Lane 2: Non-transfected lysate.

Glutaredoxin 2 Polyclonal Antibody - bs-13394R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded human colon carcinoma; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Glutaredoxin 2 Polyclonal Antibody, Unconjugated bs-13394R at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

Glutaredoxin 2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13394R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13394R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13394R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13394R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Polyclonal Antibody, Cy3 Conjugated - bs-13394R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Polyclonal Antibody, Cy5 Conjugated - bs-13394R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Polyclonal Antibody, Cy5.5 Conjugated - bs-13394R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Polyclonal Antibody, Cy7 Conjugated - bs-13394R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Polyclonal Antibody, FITC Conjugated - bs-13394R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Glutaredoxin 2 Polyclonal Antibody, Biotin Conjugated - bs-13394R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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