GLRX2

Gene Symbol GLRX2
Entrez Gene 51022
Alt Symbol CGI-133, GRX2
Species Human
Gene Type protein-coding
Description glutaredoxin 2
Other Description bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2)
Swissprots Q9NS18 Q9Y3D4 Q3LR69 Q96JC0 Q7L1N7
Accessions ABA03170 CBF61391 CBF61398 CBF61800 CBF61807 CBF64885 CBF64892 CBF65449 CBF65456 CBF69768 CBF69783 CBF71621 CBF71635 CBF72937 CBF72952 CBF74264 CBF74280 CBF82314 CBF82330 CBU86419 CBU86426 CBU86676 CBU86683 CBU89756 CBU89763 CBU90320 CBU90327 CBU94419 CBU94426 CBU95298 CBU95305 CBU95927 CBU95934 CBU96576 CBU96583 CBV00324 CBV00331 EAW91248 EAW91249 Q9NS18 AA056513 AA887118 AF132495 AAF37320 AF151891 AAD34128 AF290514 AAK83089 AY038988 AAK72499 BC009669 AAH09669 BC028113 AAH28113 BQ432881 BU157087 CN362908 XM_005245231 XP_005245288 NM_001243399 NP_001230328 NM_016066 NP_057150 NM_197962 NP_932066
Function Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:14676218, ECO:0000269|PubMed:15328416, ECO:0000269|PubMed:15649413}.
Subcellular Location Isoform 1: Mitochondrion.
Tissue Specificity Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:15184054, ECO:0000269|PubMed:15297967}.

Grx2 CRISPR/Cas9 KO Plasmid (h) - sc-412093 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Grx2 HDR Plasmid (h) - sc-412093-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Grx2 Double Nickase Plasmid (h) - sc-412093-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Grx2 Double Nickase Plasmid (h2) - sc-412093-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Grx2 CRISPR Activation Plasmid (h) - sc-412093-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Grx2 CRISPR Activation Plasmid (h2) - sc-412093-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Grx2 Lentiviral Activation Particles (h) - sc-412093-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Grx2 Lentiviral Activation Particles (h2) - sc-412093-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Grx2 siRNA (h) - sc-72090 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Grx2 shRNA Plasmid (h) - sc-72090-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Grx2 shRNA (h) Lentiviral Particles - sc-72090-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Glutaredoxin 2 RNAi - H00051022-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Glutaredoxin 2 RNAi - H00051022-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU141551 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9358 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9358 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00795 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00795

GLRX2 siRNA (Human) - CRH9462 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GLRX2 - MBS8232681 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GLRX2 (NM_197962.2) - SHH302002 from Creative biogene

Category siRNA
Species Reactivities Human

GLRX2 shRNA Plasmid (Human) - CHH9462 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GLRX2 miRNA 3'UTR clone - MiUTR4H-TG03858 from Creative biogene

Species Reactivities Human
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