GLRX2

Gene Symbol	GLRX2
Entrez Gene	51022
Alt Symbol	CGI-133, GRX2
Species	Human
Gene Type	protein-coding
Description	glutaredoxin 2
Other Description	bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2)
Swissprots	Q9NS18 Q9Y3D4 Q3LR69 Q96JC0 Q7L1N7
Accessions	ABA03170 CBF61391 CBF61398 CBF61800 CBF61807 CBF64885 CBF64892 CBF65449 CBF65456 CBF69768 CBF69783 CBF71621 CBF71635 CBF72937 CBF72952 CBF74264 CBF74280 CBF82314 CBF82330 CBU86419 CBU86426 CBU86676 CBU86683 CBU89756 CBU89763 CBU90320 CBU90327 CBU94419 CBU94426 CBU95298 CBU95305 CBU95927 CBU95934 CBU96576 CBU96583 CBV00324 CBV00331 EAW91248 EAW91249 Q9NS18 AA056513 AA887118 AF132495 AAF37320 AF151891 AAD34128 AF290514 AAK83089 AY038988 AAK72499 BC009669 AAH09669 BC028113 AAH28113 BQ432881 BU157087 CN362908 XM_005245231 XP_005245288 NM_001243399 NP_001230328 NM_016066 NP_057150 NM_197962 NP_932066
Function	Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:14676218, ECO:0000269|PubMed:15328416, ECO:0000269|PubMed:15649413}.
Subcellular Location	Isoform 1: Mitochondrion.
Tissue Specificity	Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:11297543, ECO:0000269|PubMed:15184054, ECO:0000269|PubMed:15297967}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Glutaredoxin 2 protein fragment - ab82665 from Abcam Category Protein Prices $239.00 Sizes 100 µg Source E. coli Species Human

Human Glutaredoxin 2 full length protein - ab95471 from Abcam Category Protein Source E. coli Species Human

S. cerevisiae Glutaredoxin 2 full length protein - ab63232 from Abcam Category Protein Source Saccharomyces cerevisiae Species Yeast

GLRX2 / Glutaredoxin 2 Antibody Blocking Peptide - LS-E8844 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GLRX2 / Glutaredoxin 2 Antibody Blocking Peptide - LS-E21119 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Glutaredoxin 2 Protein - NBP1-30299 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

Glutaredoxin 2 Recombinant Protein - H00051022-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Glutaredoxin 2 Recombinant Protein - P4549 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

Recombinant Bacterial Glutaredoxin 2 Protein - NBP1-72291 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli

Glutaredoxin 2 Recombinant Protein - P5003 from Novus Biologicals Category Protein Prices $549.00 Sizes 100 µg Species Bacteria

GLRX2-Antibody-C-term-C153-Blocking-peptide - BP12642b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GLRX2-Antibody-C-term-T135-Blocking-Peptide - BP7301b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GLRX2 Protein (OPPA01997) - OPPA01997 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Yeast GLRX2 protein - orb90120 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli Species Yeast

Human GLRX2 protein - orb90119 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli Species Human

GLRX2 Blocking Peptide - 33R-6922 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Glutaredoxin2 protein (His tag) - 80R-1227 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

Glutaredoxin-2 / GLRX2 (20-164, His-tag) - AR09319PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

Glutaredoxin-2 / GLRX2 (20-164, His-tag) - AR09319PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

Glutaredoxin-2 / GLRX2 - H00051022-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Glutaredoxin-2 / GLRX2 - H00051022-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Glutaredoxin-2 / GLRX2 - P4549 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

Glutaredoxin 2, Human Recombinant - 228-12484-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Glutaredoxin 2 Human - 228-12484-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Glutaredoxin 2 Human - 228-12484-3 from RayBiotech Category Protein Prices $2,400.00 Sizes 3 µg Source Escherichia Coli. Species Human

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