ACTN4

Gene Symbol	ACTN4
Entrez Gene	81
Alt Symbol	ACTININ-4, FSGS, FSGS1
Species	Human
Gene Type	protein-coding
Description	actinin, alpha 4
Other Description	F-actin cross-linking protein|actinin alpha4 isoform|alpha-actinin-4|focal segmental glomerulosclerosis 1|non-muscle alpha-actinin 4
Swissprots	O76048 D6PXK4 A4K467 O43707
Accessions	EAW56809 EAW56810 EAW56811 O43707 AA478431 AA847056 AK299955 BAG61782 AK304554 BAG65349 AK309361 AK309363 AK309364 AU118403 BC005033 AAH05033 BC015620 AAH15620 BM841805 BP332596 BX647098 D89980 BAA24447 DQ431186 ABD96103 DQ893439 ABM84365 DQ896777 ABM87776 GU987085 ADG03678 U48734 AAC17470 XM_005259281 XP_005259338 XM_005259282 XP_005259339 XM_006723406 XP_006723469 NM_004924 NP_004915
Function	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:9508771}. Cytoplasm {ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:9508771}. Cell junction {ECO:0000250|UniProtKB:P57780}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC- 2, and bladder cancer KU-7). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:9508771}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9508771}.
Top Pathways	Systemic lupus erythematosus, Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Leukocyte transendothelial migration, Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ACTN4 ELISA Kit (Sandwich ELISA) - LS-F9216 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.32 ng/ml Range 0.781-50 ng/ml

Actinin Alpha 4 (ACTN4), Human, ELISA Kit - SEC223Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.24ng/mL Range 0.78 -50ng/mL

Alpha-Actinin 1, ACTN-1, Human, ELISA Kit - CSB-E14176h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Alpha-actinin-4 (ACTN-4), Human, ELISA Kit - CSB-E13742h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.8 pg/ml Range 31.25 pg/ml-2000 pg/ml

Alpha-actinin-4 (ACTN-4), Human, ELISA Kit - E01A1227 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Alpha-actinin-4, ACTN4, Human, ELISA Kit - E1460h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/ml

ACTN4 (Human) Matched Antibody Pair - H00000081-AP41 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

ACTN4 (Human) Matched Antibody Pair - H00000081-AP42 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Actinin Alpha 4 (ACTN4), ELISA Kit - MBS2023993 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.27ng/mL. Range 0.781-50ng/mL

actinin, alpha 4, ELISA Kit - MBS702507 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <7.8 pg/ml Range 31.25 pg/ml-2000 pg/ml

ACTN4, ELISA Kit - MBS2516325 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human ACTN4 is 0.469ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). Range 0.781-50ng/mL

Alpha actinin 4 (ACTN 4), ELISA Kit - MBS7244657 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Alpha actinin-4 (ACTN-4), ELISA Kit - MBS7252067 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human ACTN4(Actinin Alpha 4) ELISA Kit - E-EL-H1636 from Elabscience Category ELISA Kit Sensitivity 0.47 ng/mL Range 0.78—50 ng/mL

alpha-actinin-4, ELISA Kit - MBS281812 from MyBioSource Category ELISA Kit Prices $440.00, $730.00, $2,970.00, $5,685.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7217428 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7216161 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7216976 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7245709 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7234197 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7208369 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7212211 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7201004 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7230448 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

alpha-actinin-4 (ACTN-4), ELISA Kit - MBS7246064 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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