ACTN4

Gene Symbol	ACTN4
Entrez Gene	81
Alt Symbol	ACTININ-4, FSGS, FSGS1
Species	Human
Gene Type	protein-coding
Description	actinin, alpha 4
Other Description	F-actin cross-linking protein|actinin alpha4 isoform|alpha-actinin-4|focal segmental glomerulosclerosis 1|non-muscle alpha-actinin 4
Swissprots	O76048 D6PXK4 A4K467 O43707
Accessions	EAW56809 EAW56810 EAW56811 O43707 AA478431 AA847056 AK299955 BAG61782 AK304554 BAG65349 AK309361 AK309363 AK309364 AU118403 BC005033 AAH05033 BC015620 AAH15620 BM841805 BP332596 BX647098 D89980 BAA24447 DQ431186 ABD96103 DQ893439 ABM84365 DQ896777 ABM87776 GU987085 ADG03678 U48734 AAC17470 XM_005259281 XP_005259338 XM_005259282 XP_005259339 XM_006723406 XP_006723469 NM_004924 NP_004915
Function	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250|UniProtKB:P57780, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:22351778, ECO:0000305|PubMed:9508771}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:9508771}. Cytoplasm {ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:9508771}. Cell junction {ECO:0000250|UniProtKB:P57780}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC- 2, and bladder cancer KU-7). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:9508771}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9508771}.
Top Pathways	Systemic lupus erythematosus, Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Leukocyte transendothelial migration, Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human alpha Actinin 4 protein fragment - ab126006 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

ACTN4 Antibody Blocking Peptide - LS-E9261 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACTN4 Antibody Blocking Peptide - LS-E9262 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ACTN4 Antibody Blocking Peptide - LS-E15524 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Alpha Actinin 4 Protein - H00000081-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Alpha Actinin 4 Protein - H00000081-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ACTN4-Antibody-C-term-Blocking-Peptide - BP7790b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ACTN4-Antibody-N-term-Blocking-Peptide - BP7790a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

alpha Actinin 4 Blocking Peptide - 33R-2213 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

alpha Actinin 4 Blocking Peptide - 33R-5045 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Alpha-actinin-4 / ACTN4 - H00000081-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Alpha-actinin-4 / ACTN4 - H00000081-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Alpha-actinin-4 / ACTN4 - H00000081-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Alpha-actinin-4 / ACTN4 - H00000081-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Alpha Actinin - 03-62002 from ARP American Research Products Category Protein Prices $419.00 Sizes 250 µg Source Chicken gizzard

ACTN4 fusion protein - Ag13546 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

ACTN4 fusion protein - Ag13549 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Recombinant Human ACTN4, GST-tagged - ACTN4-9342H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Actinin Alpha 4 (ACTN4) - RPC223Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Actinin Alpha 2 (ACTN2) - RPA376Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Actinin Alpha 4 (ACTN4) - RPC223Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Alpha-actinin-4(ACTN4) ,partial - CSB-YP001244HU CSB-EP001244HU CSB-BP001244HU CSB-MP001244HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Actinoporin Or-A - MBS2030201 from MyBioSource Category Protein Prices $210.00, $370.00, $535.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Alpha-actinin-4(ACTN4) ,partial - MBS1027636 from MyBioSource Category Protein Prices $1,020.00, $1,020.00, $1,250.00, $1,250.00, $1,550.00, $1,550.00, $2,005.00, $2,005.00 Sizes 500 µg (E Coli Derived), 50 µg (Baculovirus Derived), 500 µg (Yeast Derived), 50 µg (Mammalian Cell Derived), 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Alpha-actinin-4 / ACTN4 - TP302873 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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