| Gene Symbol |
PIN1
|
| Entrez Gene |
5300
|
| Alt Symbol |
DOD, UBL5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
|
| Other Description |
PPIase Pin1|peptidyl-prolyl cis-trans isomerase NIMA-interacting 1|protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1|rotamase Pin1
|
| Swissprots |
A8K4V9 Q13526 Q53X75
|
| Accessions |
AAM81970 EAW84057 EAW84058 EAW84059 Q13526 AF086512 AK092970 AK097558 BAG53486 AK291074 BAF83763 BC002899 AAH02899 BC031971 AAH31971 BG912418 BI827520 BI827672 BT019331 AAV38138 CA439440 CD675162 CR407654 CAG28582 DQ892978 ABM83904 DQ896226 ABM87225 U49070 AAC50492 XM_011528068 XP_011526370 NM_006221 NP_006212 NR_038422 NR_038830
|
| Function |
Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr- Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16476580}. Nucleus speckle {ECO:0000269|PubMed:21497122}. Cytoplasm {ECO:0000269|PubMed:21497122}. Note=Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). {ECO:0000269|PubMed:16476580}.
|
| Tissue Specificity |
The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. {ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway
|
![Western Blot: Pin1 Overexpression Lysate (Adult Normal) [NBL1-14428] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Pin1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14096_Pin1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14428-img0002.jpg)