| Gene Symbol |
ARHGAP17
|
| Entrez Gene |
55114
|
| Alt Symbol |
MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, PP367, PP4534, RICH-1, RICH1, WBP15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho GTPase activating protein 17
|
| Other Description |
RhoGAP interacting with CIP4 homologs 1|neuron-associated developmentally regulated protein|rho GTPase-activating protein 17|rho-type GTPase-activating protein 17
|
| Swissprots |
Q9BVF6 Q96KS3 Q7Z2F2 Q9H8U5 Q6ZUS4 Q96SS8 Q96KS2 Q8NDG2 Q9NW54 A8K6M6 Q68EM7
|
| Accessions |
EAW55778 EAW55779 EAW55780 Q68EM7 AF113218 AAG39289 AF163257 AAQ13586 AF173885 AAQ13632 AF258560 AAG23763 AF258580 AAG23783 AJ306731 CAC37948 AJ306732 CAC37949 AK001170 AK023281 BAB14506 AK027567 BAB55203 AK094886 AK125358 BAC86144 AK291691 BAF84380 AK301055 BAG62665 AK301500 BAG63011 AL833975 CAD38819 BC001241 AAH01241 BC080195 AAH80195 BI906519 BU187683 XM_011545873 XP_011544175 XM_011545874 XP_011544176 XM_011545875 XP_011544177 XM_011545876 XP_011544178 XM_011545877 XP_011544179 XM_011545878 XP_011544180 XR_950809 XR_950810 XR_950811 NM_001006634 NP_001006635 NM_018054 NP_060524
|
| Function |
Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
|
| Subcellular Location |
Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.
|
| Tissue Specificity |
Ubiquitously expressed. Expressed at higher level in heart and placenta. {ECO:0000269|PubMed:11431473}.
|