ARHGAP17

Gene Symbol	ARHGAP17
Entrez Gene	55114
Alt Symbol	MST066, MST110, MSTP038, MSTP066, MSTP110, NADRIN, PP367, PP4534, RICH-1, RICH1, WBP15
Species	Human
Gene Type	protein-coding
Description	Rho GTPase activating protein 17
Other Description	RhoGAP interacting with CIP4 homologs 1|neuron-associated developmentally regulated protein|rho GTPase-activating protein 17|rho-type GTPase-activating protein 17
Swissprots	Q9BVF6 Q96KS3 Q7Z2F2 Q9H8U5 Q6ZUS4 Q96SS8 Q96KS2 Q8NDG2 Q9NW54 A8K6M6 Q68EM7
Accessions	EAW55778 EAW55779 EAW55780 Q68EM7 AF113218 AAG39289 AF163257 AAQ13586 AF173885 AAQ13632 AF258560 AAG23763 AF258580 AAG23783 AJ306731 CAC37948 AJ306732 CAC37949 AK001170 AK023281 BAB14506 AK027567 BAB55203 AK094886 AK125358 BAC86144 AK291691 BAF84380 AK301055 BAG62665 AK301500 BAG63011 AL833975 CAD38819 BC001241 AAH01241 BC080195 AAH80195 BI906519 BU187683 XM_011545873 XP_011544175 XM_011545874 XP_011544176 XM_011545875 XP_011544177 XM_011545876 XP_011544178 XM_011545877 XP_011544179 XM_011545878 XP_011544180 XR_950809 XR_950810 XR_950811 NM_001006634 NP_001006635 NM_018054 NP_060524
Function	Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
Subcellular Location	Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.
Tissue Specificity	Ubiquitously expressed. Expressed at higher level in heart and placenta. {ECO:0000269|PubMed:11431473}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ARHGAP17 CRISPR/Cas9 KO Plasmid (h) - sc-403218 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ARHGAP17 HDR Plasmid (h) - sc-403218-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARHGAP17 Double Nickase Plasmid (h) - sc-403218-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARHGAP17 Double Nickase Plasmid (h2) - sc-403218-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARHGAP17 CRISPR Activation Plasmid (h) - sc-403218-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ARHGAP17 CRISPR Activation Plasmid (h2) - sc-403218-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ARHGAP17 Lentiviral Activation Particles (h) - sc-403218-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARHGAP17 Lentiviral Activation Particles (h2) - sc-403218-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ARHGAP17 siRNA (h) - sc-93486 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ARHGAP17 shRNA Plasmid (h) - sc-93486-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ARHGAP17 shRNA (h) Lentiviral Particles - sc-93486-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU100431 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU135511 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3411 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3411 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06273 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr06273

ARHGAP17 siRNA (Human) - CRJ0479 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ARHGAP17 - MBS8209288 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human ARHGAP17 (NM_018054.4) - SHH239342 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ARHGAP17(NM_001006634.1) - SHG069373 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ARHGAP17(NM_018054.4) - SHG069427 from Creative biogene Category siRNA Species Reactivities Human

ARHGAP17 shRNA Plasmid (Human) - CHJ0479 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

ARHGAP17 miRNA 3'UTR clone - MiUTR1H-00515 from Creative biogene Species Reactivities Human

ARHGAP17 miRNA 3'UTR clone - MiUTR1H-00516 from Creative biogene Species Reactivities Human

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