USP4

Gene Symbol USP4
Entrez Gene 7375
Alt Symbol UNP, Unph
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 4 (proto-oncogene)
Other Description deubiquitinating enzyme 4|ubiquitin carboxyl-terminal esterase 4|ubiquitin carboxyl-terminal hydrolase 4|ubiquitin specific protease 4 (proto-oncogene)|ubiquitin thioesterase 4|ubiquitin thiolesterase 4|ubiquitin-specific processing protease 4|ubiquitous nuclear protein homolog
Swissprots O43452 A8K6Y0 Q13107 O43453 Q08AK8 C9IY91
Accessions CCQ43948 EAW64968 EAW64969 EAW64970 EAW64971 EAW64972 EAW64973 Q13107 AF017305 AAC27355 AF017306 AAC27356 AI887410 AK127055 AK222725 BAD96445 AK223292 BAD97012 AK291795 BAF84484 BC068017 BC125130 AAI25131 BC125131 AAI25132 BG717217 BU632996 DA267618 DB534804 U20657 AAB72237 NM_001251877 NP_001238806 NM_003363 NP_003354 NM_199443 NP_955475
Function Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:7784062}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Nucleus {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}.
Tissue Specificity Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons. {ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:7784062}.

USP4 Antibody - 2651 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using USP4 Antibody.

USP4 (H-3) - sc-376000 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
USP4 (H-3): sc-376000. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

USP4 (H-72) - sc-292321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

USP4 (K-17) - sc-79320 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

USP4 (N-17) - sc-79321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
USP4 (N-17): sc-79321. Western blot analysis of USP4 expression in rat heart tissue extract.

USP4 (Q-19) - sc-79322 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
USP4 (Q-19): sc-79322. Western blot analysis of USP4 expression in non-transfected: sc-117752 (A) and mouse USP4 transfected: sc-124500 (B) 293T whole cell lysates.

Anti-USP4 antibody - ab38510 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-USP4 antibody (ab38510) + USP4-transfected HeLa cell lysate

Anti-USP4 antibody - ab58087 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58087 USP4 antibody at 1ug/ml.

Anti-USP4 antibody - ab70617 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human USP4 by Western Blot of Immunprecipitate. ab70617 at 1µg/ml staining USP4 (approximately 120kDa) in HeLa whole cell lysates immunoprecipitated using ab70617 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-USP4 antibody [EPR13846] - ab181105 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13846
Immunofluorescent staining of -20℃ Acetone-fixed THP1 cells labeling USP4 using ab181105 at a 1/250 dilution, followed by Goat anti rabbit IgG (Alexa Fluor® 488) secondary antibody at a 1/200 dilution and counter stained with DAPI.

Anti-USP4 Antibody (AP) - LS-C87141 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (aa2-14) - LS-C55660 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-USP4 Antibody - LS-C93279 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (aa225-275) - LS-C93278 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (aa1-30, APC) - LS-C273187 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (aa1-30, Biotin) - LS-C273188 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (aa1-30, FITC) - LS-C273189 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (aa1-30, PE) - LS-C273190 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (aa1-30, Azide-free, HRP) - LS-C273191 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (C-Terminus, APC) - LS-C284089 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (C-Terminus, Biotin) - LS-C284090 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (C-Terminus) - LS-C187278 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Jurkat . USP4 antibody dilution 1.0 ug/ml.

Anti-USP4 Antibody (C-Terminus, FITC) - LS-C284091 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-USP4 Antibody (clone 5E12) - LS-C198411 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5E12
Western Blot analysis of USP4 expression in transfected 293T cell line by USP4 monoclonal antibody (M01), clone 5E12.Lane 1: USP4 transfected lysate (Predicted MW: 108.6 KDa).Lane 2: Non-transfected lysate.

Anti-USP4 Antibody (C-Terminus, Azide-free, HRP) - LS-C284092 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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