USP4

Gene Symbol USP4
Entrez Gene 7375
Alt Symbol UNP, Unph
Species Human
Gene Type protein-coding
Description ubiquitin specific peptidase 4 (proto-oncogene)
Other Description deubiquitinating enzyme 4|ubiquitin carboxyl-terminal esterase 4|ubiquitin carboxyl-terminal hydrolase 4|ubiquitin specific protease 4 (proto-oncogene)|ubiquitin thioesterase 4|ubiquitin thiolesterase 4|ubiquitin-specific processing protease 4|ubiquitous nuclear protein homolog
Swissprots O43452 A8K6Y0 Q13107 O43453 Q08AK8 C9IY91
Accessions CCQ43948 EAW64968 EAW64969 EAW64970 EAW64971 EAW64972 EAW64973 Q13107 AF017305 AAC27355 AF017306 AAC27356 AI887410 AK127055 AK222725 BAD96445 AK223292 BAD97012 AK291795 BAF84484 BC068017 BC125130 AAI25131 BC125131 AAI25132 BG717217 BU632996 DA267618 DB534804 U20657 AAB72237 NM_001251877 NP_001238806 NM_003363 NP_003354 NM_199443 NP_955475
Function Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:7784062}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Nucleus {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}.
Tissue Specificity Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons. {ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:7784062}.

USP4 CRISPR/Cas9 KO Plasmid (h) - sc-403543 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP4 HDR Plasmid (h) - sc-403543-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP4 Double Nickase Plasmid (h) - sc-403543-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP4 Double Nickase Plasmid (h2) - sc-403543-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP4 CRISPR Activation Plasmid (h) - sc-403543-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP4 CRISPR Activation Plasmid (h2) - sc-403543-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP4 Lentiviral Activation Particles (h) - sc-403543-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP4 Lentiviral Activation Particles (h2) - sc-403543-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

USP4 siRNA (h) - sc-76851 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP4 shRNA Plasmid (h) - sc-76851-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP4 shRNA (h) Lentiviral Particles - sc-76851-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP4 RNAi - H00007375-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

USP4 RNAi - H00007375-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU089041 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22589 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22589 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06074 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06074

USP4 siRNA (Human) - CRH5045 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USP4 - MBS8234046 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human USP4 (NM_003363.3) - SHH441584 from Creative biogene

Category siRNA
Species Reactivities Human

Human USP4 siRNA - orb265547 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

USP4 shRNA Plasmid (Human) - CHH5045 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

USP4 miRNA 3'UTR clone - MiUTR3H-06015 from Creative biogene

Species Reactivities Human

USP4 miRNA 3'UTR clone - MiUTR3H-06016 from Creative biogene

Species Reactivities Human
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