USP4

Gene Symbol	USP4
Entrez Gene	7375
Alt Symbol	UNP, Unph
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 4 (proto-oncogene)
Other Description	deubiquitinating enzyme 4|ubiquitin carboxyl-terminal esterase 4|ubiquitin carboxyl-terminal hydrolase 4|ubiquitin specific protease 4 (proto-oncogene)|ubiquitin thioesterase 4|ubiquitin thiolesterase 4|ubiquitin-specific processing protease 4|ubiquitous nuclear protein homolog
Swissprots	O43452 A8K6Y0 Q13107 O43453 Q08AK8 C9IY91
Accessions	CCQ43948 EAW64968 EAW64969 EAW64970 EAW64971 EAW64972 EAW64973 Q13107 AF017305 AAC27355 AF017306 AAC27356 AI887410 AK127055 AK222725 BAD96445 AK223292 BAD97012 AK291795 BAF84484 BC068017 BC125130 AAI25131 BC125131 AAI25132 BG717217 BU632996 DA267618 DB534804 U20657 AAB72237 NM_001251877 NP_001238806 NM_003363 NP_003354 NM_199443 NP_955475
Function	Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:7784062}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Nucleus {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}.
Tissue Specificity	Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons. {ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:7784062}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human USP4 full length protein - ab131959 from Abcam Category Protein Source Wheat germ Species Human

Human USP4 peptide - ab23051 from Abcam Category Peptide Species Human

Human USP4 protein fragment - ab159783 from Abcam Category Protein Source Wheat germ Species Human

USP4 Antibody Blocking Peptide - LS-E3472 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP4 Antibody Blocking Peptide - LS-E25549 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP4 Antibody Blocking Peptide - LS-E29436 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

USP4 Antibody Blocking Peptide - LS-E29437 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

USP4 Antibody Blocking Peptide - LS-E29438 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

USP4 Antibody Blocking Peptide - LS-E22951 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP4 Antibody Blocking Peptide - LS-E6880 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human USP4 Protein - H00007375-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

USP4 Partial Recombinant Protein - H00007375-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

USP4 Peptide - P0920 from Novus Biologicals Category Peptide Species Human

USP4-Antibody-N-term-Blocking-Peptide - BP14657a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP4-Antibody-C-term-Blocking-Peptide - BP2133b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP4 blocking peptide - GTX24546-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

USP4 Peptide - AC21-0378-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

USP4 / UNP - H00007375-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

USP4 / UNP - H00007375-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

USP4 / UNP - H00007375-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

USP4 / UNP - H00007375-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

USP4 Peptide - 46-564P from ProSci Category Peptide Species Human

Recombinant Human USP4, His-tagged - USP4-183H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human USP4 - USP4-156H from Creative Biomart Category Protein Source Insect Cells Species Human

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 4(USP4) ,partial - CSB-YP614393HU CSB-EP614393HU CSB-BP614393HU CSB-MP614393HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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