| Gene Symbol |
USP4
|
| Entrez Gene |
7375
|
| Alt Symbol |
UNP, Unph
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 4 (proto-oncogene)
|
| Other Description |
deubiquitinating enzyme 4|ubiquitin carboxyl-terminal esterase 4|ubiquitin carboxyl-terminal hydrolase 4|ubiquitin specific protease 4 (proto-oncogene)|ubiquitin thioesterase 4|ubiquitin thiolesterase 4|ubiquitin-specific processing protease 4|ubiquitous nuclear protein homolog
|
| Swissprots |
O43452 A8K6Y0 Q13107 O43453 Q08AK8 C9IY91
|
| Accessions |
CCQ43948 EAW64968 EAW64969 EAW64970 EAW64971 EAW64972 EAW64973 Q13107 AF017305 AAC27355 AF017306 AAC27356 AI887410 AK127055 AK222725 BAD96445 AK223292 BAD97012 AK291795 BAF84484 BC068017 BC125130 AAI25131 BC125131 AAI25132 BG717217 BU632996 DA267618 DB534804 U20657 AAB72237 NM_001251877 NP_001238806 NM_003363 NP_003354 NM_199443 NP_955475
|
| Function |
Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:16472766, ECO:0000269|PubMed:20595234, ECO:0000269|PubMed:7784062}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Nucleus {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}.
|
| Tissue Specificity |
Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons. {ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:7784062}.
|