PAWR

Gene Symbol	PAWR
Entrez Gene	5074
Alt Symbol	PAR4, Par-4
Species	Human
Gene Type	protein-coding
Description	PRKC, apoptosis, WT1, regulator
Other Description	PRKC apoptosis WT1 regulator protein|WT1-interacting protein|prostate apoptosis response 4 protein|prostate apoptosis response protein 4|prostate apoptosis response protein PAR-4|prostate apoptosis response-4|transcriptional repressor PAR4
Swissprots	O75796 Q6FHY9 Q96IZ0 Q8N700
Accessions	AAM27453 AAN23144 AAP43693 CCQ43185 EAW97346 EAW97347 EAW97348 EAW97349 Q96IZ0 AK027848 AK095165 BC007018 AAH07018 BC009637 CA313080 CN280333 CR536549 CAG38786 U63809 AAC24947 XM_006719435 XP_006719498 XM_006719436 XP_006719499 XR_944560 XR_944561 NM_002583 NP_002574
Function	Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}.
Subcellular Location	Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}.
Tissue Specificity	Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. {ECO:0000269|PubMed:8943350}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat PAWR / PAR4 ELISA Kit (Cell-Based ELISA) - LS-F2270 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Human PAR4 ELISA Kit - abx152640 from Abbexa Category ELISA Kit Sensitivity 0.129 ng/ml Range 0.313 ng/ml - 20 ng/ml

Protease Activated Receptor 4, PAR4, Human, ELISA Kit - E-EL-H1280 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

PRKC apoptosis WT1 regulator protein (PAWR), Human, ELISA Kit - CSB-EL017486HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Protease Activated Receptor 4, PAR4, Rabbit, ELISA Kit - E-EL-RB0674 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protease Activated Receptor 4, PAR4, Chicken, ELISA Kit - E-EL-Ch0888 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Protease Activated Receptor 4, PAR4, Porcine, ELISA Kit - E-EL-P2248 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protease Activated Receptor 4, PAR4, Sheep, ELISA Kit - E-EL-S0113 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Protease Activated Receptor 4, PAR4, Monkey, ELISA Kit - E-EL-MK1261 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Prostate Apoptosis Response protein-4 Colorimetric Cell-Based ELISA Kit - CB5588 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human PAR4(Protease Activated Receptor 4) ELISA Kit - E-EL-H1280 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human PAR4 (Protease Activated Receptor 4) CLIA Kit - E-CL-H0834 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

PRKC apoptosis WT1 regulator protein, ELISA Kit - MBS281365 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

PRKC, apoptosis, WT1, regulator, ELISA Kit - MBS943631 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human PAWR is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml -1600 pg/ml.

ELISA Kit for Prostate Apoptosis Response 4 (PAR4) - SEL991Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human PRKC apoptosis WT1 regulator protein(PAWR) ELISA kit - CSB-EL017486HU from Cusabio Category ELISA Kit Sensitivity 6.25pg/ml Range 25 pg/ml-1600 pg/ml

ELISA Kit for Prostate Apoptosis Response 4 (PAR4) - SEL991Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human PAR4(Protease Activated Receptor 4) ELISA Kit - E-EL-H1280 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.19 ng/mLng/mL Range 0.31~20 ng/mL

Human PAR4 (Protease Activated Receptor 4) CLIA Kit - E-CL-H0834 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.188ng/mL Range 0.313-20ng/mL

Protease Activated Receptor 4 (PAR4), Human, ELISA Kit - DL-PAR4-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human PAWR / PAR4 ELISA Kit (Sandwich ELISA) - LS-F25598 from LifeSpan Bioscience Category ELISA Kit Prices $850.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Human PAR4 ELISA Kit - abx572607 from Abbexa Category ELISA Kit Sensitivity 0.129 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human PAWR ELISA Kit - E030626 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human PAWR is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

Human PAR4 ELISA Kit - E031383 from Biobool Category ELISA Kit Sensitivity 1.0 ng/mL.

PAWR ELISA Kit (Human) (OKCA00758) - OKCA00758 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 6.25 pg/mL Range 25 pg/mL-1,600 pg/mL

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