PAWR

Gene Symbol	PAWR
Entrez Gene	5074
Alt Symbol	PAR4, Par-4
Species	Human
Gene Type	protein-coding
Description	PRKC, apoptosis, WT1, regulator
Other Description	PRKC apoptosis WT1 regulator protein|WT1-interacting protein|prostate apoptosis response 4 protein|prostate apoptosis response protein 4|prostate apoptosis response protein PAR-4|prostate apoptosis response-4|transcriptional repressor PAR4
Swissprots	O75796 Q6FHY9 Q96IZ0 Q8N700
Accessions	AAM27453 AAN23144 AAP43693 CCQ43185 EAW97346 EAW97347 EAW97348 EAW97349 Q96IZ0 AK027848 AK095165 BC007018 AAH07018 BC009637 CA313080 CN280333 CR536549 CAG38786 U63809 AAC24947 XM_006719435 XP_006719498 XM_006719436 XP_006719499 XR_944560 XR_944561 NM_002583 NP_002574
Function	Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}.
Subcellular Location	Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}.
Tissue Specificity	Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. {ECO:0000269|PubMed:8943350}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PAR4 protein fragment - ab114724 from Abcam Category Protein Source Wheat germ Species Human

PAR4 peptide - ab5853 from Abcam Category Peptide

PAWR / PAR4 Antibody Blocking Peptide - LS-E11510 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAWR / PAR4 Antibody Blocking Peptide - LS-E11205 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAWR / PAR4 Partial Recombinant Protein - H00005074-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PAR4 Blocking Peptide - 33R-10764 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

PAWR Blocking Peptide - abx063047 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog

PAR4 / PAWR - H00005074-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PAR4 / PAWR - H00005074-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PAR4 / PAWR control peptide - SP5271CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

PAR-4 (1-6) (human) - 89792 from NeoScientific Category Peptide Prices $57.00, $85.00, $170.00 Sizes 5 mg, 10 mg, 25 mg Species Human

Recombinant Human PAWR - PAWR-28664TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PAWR, MYC/DDK-tagged - PAWR-19H from Creative Biomart Category Protein Source HEK293 cells Species Human

PAWR Blocking Peptide - CBP1853 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken, Dog

PAR4 (D313) Peptide - BS1300P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human PRKC apoptosis WT1 regulator protein(PAWR) - CSB-YP842688HU CSB-EP842688HU CSB-BP842688HU CSB-MP842688HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PAR4 Blocking Peptide - 3447BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

PAR 4 (1-6) - 3494 from R&D Systems Category Peptide Prices $135.00 Sizes 5 mg

PAR4 Blocking Peptide - abx161849 from Abbexa Category Peptide Species Human

PAR4 / PAWR - TP302733 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PRKC apoptosis WT1 regulator protein (PAWR), Recombinant Protein - MBS1473166 from MyBioSource Category Protein Prices $1,105.00, $1,105.00, $1,335.00, $1,335.00, $1,740.00, $1,740.00, $2,205.00, $2,205.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PAWR / PAR4 Recombinant Protein Antigen - NBP1-87338PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PAR-4 (1-6) - abx265069 from Abbexa Source Human Species Human

PAWR-Antibody-Center-Blocking-Peptide - BP9439c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAWR-Antibody-C-term-Blocking-Peptide - BP9439b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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