| Gene Symbol |
PAWR
|
| Entrez Gene |
5074
|
| Alt Symbol |
PAR4, Par-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PRKC, apoptosis, WT1, regulator
|
| Other Description |
PRKC apoptosis WT1 regulator protein|WT1-interacting protein|prostate apoptosis response 4 protein|prostate apoptosis response protein 4|prostate apoptosis response protein PAR-4|prostate apoptosis response-4|transcriptional repressor PAR4
|
| Swissprots |
O75796 Q6FHY9 Q96IZ0 Q8N700
|
| Accessions |
AAM27453 AAN23144 AAP43693 CCQ43185 EAW97346 EAW97347 EAW97348 EAW97349 Q96IZ0 AK027848 AK095165 BC007018 AAH07018 BC009637 CA313080 CN280333 CR536549 CAG38786 U63809 AAC24947 XM_006719435 XP_006719498 XM_006719436 XP_006719499 XR_944560 XR_944561 NM_002583 NP_002574
|
| Function |
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. {ECO:0000269|PubMed:11585763}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. {ECO:0000269|PubMed:8943350}.
|