TNFAIP8

Gene Symbol TNFAIP8
Entrez Gene 25816
Alt Symbol GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2
Species Human
Gene Type protein-coding
Description tumor necrosis factor, alpha-induced protein 8
Other Description NF-kappa-B-inducible DED-containing protein|TNF alpha-induced protein 8|TNF-induced protein GG2-1|head and neck tumor and metastasis-related protein|tumor necrosis factor alpha-induced protein 8
Swissprots Q9P1Q1 B3KMH1 B7Z713 B3KMI2 O95379 Q9UP47 Q9UER5
Accessions EAW48913 EAW48914 O95379 AF070671 AAC83229 AF098933 AAF29435 AF098934 AF099935 AAC72975 AF099936 AAC72976 AK001850 BAG50983 AK001931 BAG50994 AK097284 BAG53444 AK097884 AK301281 BAH13449 BC005352 AAH05352 BC007014 AAH07014 BE958495 BP274520 CB241243 CR457137 CAG33418 DA278032 DB114867 DB124282 DC391074 HQ448379 ADQ32859 NM_001077654 NP_001071122 NM_001286813 NP_001273742 NM_001286814 NP_001273743 NM_001286815 NP_001273744 NM_001286817 NP_001273746 NM_014350 NP_055165
Function Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. {ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14724590}.
Tissue Specificity Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. {ECO:0000269|PubMed:10233894, ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:14724590}.

TNFα-IP 8 (C-14) - sc-82054 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TNFα-IP 8 (C-14): sc-82054. Western blot analysis of TNF-IP 8 expression in non-transfected 293T: sc-117752 (A), human TNF-IP 8 transfected 293T: sc-371558 (B), HUV-EC-C (C) and A549 (D) whole cell lysates.

TNFα-IP 8 (L-15) - sc-82055 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TNFAIP8 antibody - ab64988 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TNFAIP8 antibody (ab64988) at 1/500 dilutionLane 1 : Extracts from HUVEC cellsLane 2 : Extracts from HUVEC cells with immunizing peptide at 5 µgLysates/proteins at 10 µg per lane.

Anti-TNFAIP8 antibody - ab166804 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TNFAIP8 antibody (ab166804) at 1/100 dilutionLane 1 : HuvEc cell extractLane 2 : HuvEc cell extract with immunizing peptide

Anti-TNFAIP8 antibody - ab107684 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TNFAIP8 antibody (ab107684) at 1/100 dilution + K562 cell line lysate at 35 µg

Anti-TNFAIP8 antibody [EPR10058(3)] - ab195810 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10058(3)
All lanes : Anti-TNFAIP8 antibody [EPR10058(3)] (ab195810) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : A549 cell lysateLane 3 : A431 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-TNFAIP8 / SCC-S2 Antibody (aa50-78, AP) - LS-C271840 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFAIP8 / SCC-S2 Antibody (aa50-78, APC) - LS-C271841 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFAIP8 / SCC-S2 Antibody (aa50-78, Biotin) - LS-C271842 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFAIP8 / SCC-S2 Antibody (aa50-78, FITC) - LS-C271843 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFAIP8 / SCC-S2 Antibody (aa50-78, PE) - LS-C271848 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFAIP8 / SCC-S2 Antibody (aa50-78, Azide-free, HRP) - LS-C271845 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFAIP8 / SCC-S2 Antibody (aa71-116) - LS-C313980 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFAIP8 / SCC-S2 Antibody (aa50-78) - LS-C330234 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFAIP8 / SCC-S2 Antibody (aa50-78) - LS-C162053 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TNFAIP8 Antibody western blot of K562 cell line lysates (35 ug/lane). The TNFAIP8 antibody detected the TNFAIP8 protein (arrow).

Anti-TNFAIP8 / SCC-S2 Antibody (aa31-80) IHC-plus™ - LS-B8399 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SCC-S2 / TNFAIP8 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8399 dilution 5 ug/ml.

TNFAIP8 Antibody - NBP2-33814 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TNFAIP8 Antibody [NBP2-33814] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4

TNFAIP8 Antibody - H00025816-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: TNFAIP8 Antibody [H00025816-B01P] - Analysis of TNFAIP8 expression in transfected 293T cell line by TNFAIP8 polyclonal antibody. Lane 1: TNFAIP8 transfected lysate(20.9 KDa). Lane 2: Non-transfected lysate.

TNFAIP8 Antibody - NBP1-33406 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TNFAIP8 Antibody [NBP1-33406] - Sample (30 ug of whole cell lysate) A: A431 12% SDS PAGE; antibody diluted at 1:5000.

TNFAIP8 Antibody - H00025816-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: TNFAIP8 Antibody [H00025816-B01] - analysis of TNFAIP8 expression in transfected 293T cell line by TNFAIP8 MaxPab polyclonal antibody (B01). Lane 1: TNFAIP8 transfected lysate (22.00 KDa). Lane 2: Non-transfected lysate.

TNFAIP8 Antibody - H00025816-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Rabbit Anti-TNFAIP8 Polyclonal Antibody - bs-5946R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat spleen labeled with Anti-TNFAIP8 Polyclonal Antibody, Unconjugated (bs-5946R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Anti-TNFAIP8 antibody produced in rabbit - HPA057089 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TNFAIP8: <B>Cat. No. HPA057089</B>: Immunohistochemical staining of Human bone marrow shows moderate cytoplasmic positivity in hematopoietic cells.

Anti-TNFAIP8 antibody produced in mouse - SAB1407255 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TNFAIP8: <B>Cat. No. SAB1407255</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~20.9 kDa using TNFAIP8 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-TFIP8 antibody produced in rabbit - SAB4501081 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TFIP8: <B>Cat. No. SAB4501081</B>: Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using Anti-TFIP8 antibody. Cells on the left were treated with the Anti-TFIP8 antibody. Cells on the right (negative control) were treated with both Anti-TFIP8 antibody and the synthesized immunogen peptide.
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