TNFAIP8
| Gene Symbol | TNFAIP8 |
|---|---|
| Entrez Gene | 25816 |
| Alt Symbol | GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor, alpha-induced protein 8 |
| Other Description | NF-kappa-B-inducible DED-containing protein|TNF alpha-induced protein 8|TNF-induced protein GG2-1|head and neck tumor and metastasis-related protein|tumor necrosis factor alpha-induced protein 8 |
| Swissprots | Q9P1Q1 B3KMH1 B7Z713 B3KMI2 O95379 Q9UP47 Q9UER5 |
| Accessions | EAW48913 EAW48914 O95379 AF070671 AAC83229 AF098933 AAF29435 AF098934 AF099935 AAC72975 AF099936 AAC72976 AK001850 BAG50983 AK001931 BAG50994 AK097284 BAG53444 AK097884 AK301281 BAH13449 BC005352 AAH05352 BC007014 AAH07014 BE958495 BP274520 CB241243 CR457137 CAG33418 DA278032 DB114867 DB124282 DC391074 HQ448379 ADQ32859 NM_001077654 NP_001071122 NM_001286813 NP_001273742 NM_001286814 NP_001273743 NM_001286815 NP_001273744 NM_001286817 NP_001273746 NM_014350 NP_055165 |
| Function | Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. {ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:11346652, ECO:0000269|PubMed:14724590}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14724590}. |
| Tissue Specificity | Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. {ECO:0000269|PubMed:10233894, ECO:0000269|PubMed:10644768, ECO:0000269|PubMed:14724590}. |
TNF-IP 8 CRISPR/Cas9 KO Plasmid (h) - sc-411806 from Santa Cruz Biotechnology
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TNF-IP 8 HDR Plasmid (h) - sc-411806-HDR from Santa Cruz Biotechnology
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TNF-IP 8 Double Nickase Plasmid (h) - sc-411806-NIC from Santa Cruz Biotechnology
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TNF-IP 8 Double Nickase Plasmid (h2) - sc-411806-NIC-2 from Santa Cruz Biotechnology
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TNF-IP 8 CRISPR Activation Plasmid (h) - sc-411806-ACT from Santa Cruz Biotechnology
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TNF-IP 8 CRISPR Activation Plasmid (h2) - sc-411806-ACT-2 from Santa Cruz Biotechnology
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TNF-IP 8 Lentiviral Activation Particles (h) - sc-411806-LAC from Santa Cruz Biotechnology
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TNF-IP 8 Lentiviral Activation Particles (h2) - sc-411806-LAC-2 from Santa Cruz Biotechnology
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TNFα-IP 8 siRNA (h) - sc-76698 from Santa Cruz Biotechnology
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TNFα-IP 8 shRNA Plasmid (h) - sc-76698-SH from Santa Cruz Biotechnology
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TNFα-IP 8 shRNA (h) Lentiviral Particles - sc-76698-V from Santa Cruz Biotechnology
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TNFAIP8 RNAi - H00025816-R02 from Novus Biologicals
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MISSION® esiRNA - EHU054891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21734 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21734 from Sigma-Aldrich
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TNFAIP8 siRNA (Human) - CRH8515 from Cohesion Biosciences
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TNFAIP8 RNAi - H00025816-R01 from Novus Biologicals
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TNFAIP8 - MBS8224401 from MyBioSource
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shRNA set against Human TNFAIP8 (NM_014350.2) - SHH431804 from Creative biogene
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shRNA set against Human TNFAIP8(NM_001077654.1) - SHL084114 from Creative biogene
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shRNA set against Human TNFAIP8(NM_014350.2) - SHL084150 from Creative biogene
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Human TNFAIP8 siRNA - orb269017 from Biorbyt
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TNFAIP8 shRNA Plasmid (Human) - CHH8515 from Cohesion Biosciences
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TNFAIP8 miRNA 3'UTR clone - MiUTR1H-10590 from Creative biogene
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TNFAIP8 miRNA 3'UTR clone - MiUTR1H-10591 from Creative biogene
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