Gene Symbol | FAAH |
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Entrez Gene | 2166 |
Alt Symbol | FAAH-1, PSAB |
Species | Human |
Gene Type | protein-coding |
Description | fatty acid amide hydrolase |
Other Description | anandamide amidohydrolase 1|fatty-acid amide hydrolase 1|oleamide hydrolase 1 |
Swissprots | Q52M86 Q5TDF8 D3DQ19 O00519 |
Accessions | AAD13768 AAV88095 O00519 AL050372 CAB62530 BC034478 BC093632 AAH93632 BC110404 AAI10405 BC111941 AAI11942 BG718115 U82535 AAB58505 NM_001441 NP_001432 |
Function | Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. {ECO:0000269|PubMed:17015445}. |
Subcellular Location | Endomembrane system {ECO:0000269|PubMed:17015445}; Single-pass membrane protein {ECO:0000269|PubMed:17015445}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17015445}. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network. |
Tissue Specificity | Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. {ECO:0000269|PubMed:17015445}. |
Top Pathways | Retrograde endocannabinoid signaling |
FAAH1 (C84F1) Rabbit mAb - 3829 from Cell Signaling Technology
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FAAH1 (L14B8) Mouse mAb - 2942 from Cell Signaling Technology
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FAAH1 Antibody (Rat Specific) - 9179 from Cell Signaling Technology
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FAAH (V-17) - sc-26427 from Santa Cruz Biotechnology
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FAAH (H-50) - sc-366008 from Santa Cruz Biotechnology
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FAAH (C-20) - sc-26428 from Santa Cruz Biotechnology
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FAAH (27-Y) - sc-100739 from Santa Cruz Biotechnology
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Anti-FAAH1 antibody - ab54615 from Abcam
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Anti-FAAH1 antibody - ab98065 from Abcam
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Anti-FAAH1 antibody - ab107526 from Abcam
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Anti-FAAH1 antibody - ab110840 from Abcam
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Anti-FAAH1 antibody [EPR7549] - ab128917 from Abcam
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Anti-FAAH1 antibody - C-terminal - ab153729 from Abcam
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Anti-FAAH Antibody (N-Terminus) - LS-C23484 from LifeSpan Bioscience
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Anti-FAAH Antibody (N-Terminus) - LS-C23483 from LifeSpan Bioscience
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Anti-FAAH Antibody - LS-C128961 from LifeSpan Bioscience
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Anti-FAAH Antibody (aa480-580, clone 10C197, Azide-free) - LS-C183616 from LifeSpan Bioscience
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Anti-FAAH Antibody (aa501-529, APC) - LS-C214104 from LifeSpan Bioscience
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Anti-FAAH Antibody (aa501-529, AP) - LS-C214103 from LifeSpan Bioscience
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Anti-FAAH Antibody (aa501-529, Biotin) - LS-C214105 from LifeSpan Bioscience
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Anti-FAAH Antibody (aa501-529, FITC) - LS-C214106 from LifeSpan Bioscience
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Anti-FAAH Antibody (aa501-529, PE) - LS-C214108 from LifeSpan Bioscience
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Anti-FAAH Antibody (aa501-529, Azide-free, HRP) - LS-C214107 from LifeSpan Bioscience
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Anti-FAAH Antibody - LS-C192430 from LifeSpan Bioscience
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Anti-FAAH Antibody - LS-C11190 from LifeSpan Bioscience
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