Gene Symbol | FAAH |
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Entrez Gene | 2166 |
Alt Symbol | FAAH-1, PSAB |
Species | Human |
Gene Type | protein-coding |
Description | fatty acid amide hydrolase |
Other Description | anandamide amidohydrolase 1|fatty-acid amide hydrolase 1|oleamide hydrolase 1 |
Swissprots | Q52M86 Q5TDF8 D3DQ19 O00519 |
Accessions | AAD13768 AAV88095 O00519 AL050372 CAB62530 BC034478 BC093632 AAH93632 BC110404 AAI10405 BC111941 AAI11942 BG718115 U82535 AAB58505 NM_001441 NP_001432 |
Function | Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. {ECO:0000269|PubMed:17015445}. |
Subcellular Location | Endomembrane system {ECO:0000269|PubMed:17015445}; Single-pass membrane protein {ECO:0000269|PubMed:17015445}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17015445}. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network. |
Tissue Specificity | Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. {ECO:0000269|PubMed:17015445}. |
Top Pathways | Retrograde endocannabinoid signaling |
FAAH CRISPR/Cas9 KO Plasmid (h) - sc-402470 from Santa Cruz Biotechnology
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FAAH HDR Plasmid (h) - sc-402470-HDR from Santa Cruz Biotechnology
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FAAH Double Nickase Plasmid (h) - sc-402470-NIC from Santa Cruz Biotechnology
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FAAH Double Nickase Plasmid (h2) - sc-402470-NIC-2 from Santa Cruz Biotechnology
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FAAH CRISPR Activation Plasmid (h) - sc-402470-ACT from Santa Cruz Biotechnology
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FAAH CRISPR Activation Plasmid (h2) - sc-402470-ACT-2 from Santa Cruz Biotechnology
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FAAH Lentiviral Activation Particles (h) - sc-402470-LAC from Santa Cruz Biotechnology
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FAAH Lentiviral Activation Particles (h2) - sc-402470-LAC-2 from Santa Cruz Biotechnology
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FAAH siRNA (h) - sc-106807 from Santa Cruz Biotechnology
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FAAH shRNA Plasmid (h) - sc-106807-SH from Santa Cruz Biotechnology
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FAAH shRNA (h) Lentiviral Particles - sc-106807-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU098921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8077 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8077 from Sigma-Aldrich
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FAAH siRNA (Human) - CRH1506 from Cohesion Biosciences
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FAAH - MBS8202143 from MyBioSource
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FAAH CRISPR/Cas9 KO Plasmid (h2) - sc-402470-KO-2 from Santa Cruz Biotechnology
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FAAH HDR Plasmid (h2) - sc-402470-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human FAAH (NM_001441.2) - SHH288565 from Creative biogene
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shRNA set against Human FAAH(NM_001441.2) - SHH043841 from Creative biogene
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Human FAAH siRNA - orb262008 from Biorbyt
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FAAH shRNA Plasmid (Human) - CHH1506 from Cohesion Biosciences
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FAAH miRNA 3'UTR clone - MiUTR1H-03369 from Creative biogene
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