| Gene Symbol |
FAAH
|
| Entrez Gene |
2166
|
| Alt Symbol |
FAAH-1, PSAB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fatty acid amide hydrolase
|
| Other Description |
anandamide amidohydrolase 1|fatty-acid amide hydrolase 1|oleamide hydrolase 1
|
| Swissprots |
Q52M86 Q5TDF8 D3DQ19 O00519
|
| Accessions |
AAD13768 AAV88095 O00519 AL050372 CAB62530 BC034478 BC093632 AAH93632 BC110404 AAI10405 BC111941 AAI11942 BG718115 U82535 AAB58505 NM_001441 NP_001432
|
| Function |
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. {ECO:0000269|PubMed:17015445}.
|
| Subcellular Location |
Endomembrane system {ECO:0000269|PubMed:17015445}; Single-pass membrane protein {ECO:0000269|PubMed:17015445}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17015445}. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
|
| Tissue Specificity |
Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate. {ECO:0000269|PubMed:17015445}.
|
| Top Pathways |
Retrograde endocannabinoid signaling
|